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http://hdl.handle.net/1942/41717
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DC Field | Value | Language |
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dc.contributor.author | Barham, David W. | - |
dc.contributor.author | Pyrgidis, Nikolaos | - |
dc.contributor.author | Gross, Martin S. | - |
dc.contributor.author | Hammad, Muhammed | - |
dc.contributor.author | Swerdloff, Daniel | - |
dc.contributor.author | Miller, Jake | - |
dc.contributor.author | Alkhayal, Abdullah | - |
dc.contributor.author | Alrabeeah, Khalid A. | - |
dc.contributor.author | Andrianne, Robert | - |
dc.contributor.author | Burnett, Arthur L. | - |
dc.contributor.author | Gross, Kelli | - |
dc.contributor.author | Hatzichristodoulou, Georgios | - |
dc.contributor.author | Hotaling, James M. | - |
dc.contributor.author | Hsieh, Tung-Chin | - |
dc.contributor.author | Jones, Adam | - |
dc.contributor.author | Jones, James M. | - |
dc.contributor.author | Lentz, Aaron | - |
dc.contributor.author | Levy, Jason | - |
dc.contributor.author | Modgil, Vaibhav | - |
dc.contributor.author | Osmonov, Daniar | - |
dc.contributor.author | Park, Sung Hun | - |
dc.contributor.author | Pearce, Ian | - |
dc.contributor.author | Perito, Paul | - |
dc.contributor.author | Sadeghi-Nejad, Hossein | - |
dc.contributor.author | Sempels, Maxime | - |
dc.contributor.author | Suarez-Sarmiento, Alfredo, Jr. | - |
dc.contributor.author | Simhan, Jay | - |
dc.contributor.author | VAN RENTERGHEM, Koenraad | - |
dc.contributor.author | Warner, J. Nicholas | - |
dc.contributor.author | Ziegelmann, Matthew | - |
dc.contributor.author | Yafi, Faysal A. | - |
dc.date.accessioned | 2023-11-10T08:41:25Z | - |
dc.date.available | 2023-11-10T08:41:25Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-11-10T08:39:21Z | - |
dc.identifier.citation | JOURNAL OF UROLOGY, 209 (2) , p. 399 -406 | - |
dc.identifier.issn | 0022-5347 | - |
dc.identifier.uri | http://hdl.handle.net/1942/41717 | - |
dc.description.abstract | Purpose: Our aim was to determine if the AUA-recommended prophylaxis (vancomycin+gentamicin alone) for primary inflatable penile prosthesis surgery is associated with a higher infection risk than nonstandard regimens. Materials and Methods: We performed a multicenter, retrospective study of patients undergoing primary inflatable penile prosthesis surgery. Patients were divided into those receiving vancomycin + gentamicin alone and those receiving any other regimen. A Cox proportional-hazards model was constructed adjusted for major predictors. A subgroup analysis to identify the appropriate dosage of gentamicin was also performed. Results: A total of 4,161 patients underwent primary inflatable penile prosthesis placement (2,411 received vancomycin + gentamicin alone and 1,750 received other regimens). The infection rate was similar between groups, 1% vs 1.2% for standard vs nonstandard prophylaxis. In the multivariable analysis, vancomycin + gentamicin (HR: 2.7, 95% CI: 1.4 to 5.4, P = .004) and diabetes (HR: 1.9, 95% CI: 1.03 to 3.4, P = .04) were significantly associated with a higher risk of infection. Antifungals (HR: 0.08, 95% CI: 0.03 to 0.19, P <.001) were associated with lower risk of infection. There was no statistically significant difference in infection rate between weight-based gentamicin compared to 80 mg gentamicin (HR: 2.9, 95% CI: 0.83 to 10, P = .1). Conclusions: Vancomycin + gentamicin alone for antibiotic prophylaxis for primary inflatable penile prosthesis surgery is associated with a higher infection risk than nonstandard antibiotic regimens while antifungal use is associated with lower infection risk. A critical review of the recommended antimicrobial prophylactic regimens is needed. Prospective research is needed to further elucidate best practices in inflatable penile prosthesis antimicrobial prophylaxis. | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.rights | 2022 by American Urological Association Education and Research, Inc. | - |
dc.subject.other | erectile dysfunction | - |
dc.subject.other | penile prosthesis | - |
dc.subject.other | infections | - |
dc.title | AUA-recommended Antibiotic Prophylaxis for Primary Penile Implantation Results in a Higher, Not Lower, Risk for Postoperative Infection: A Multicenter Analysis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 406 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 399 | - |
dc.identifier.volume | 209 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Barham, DW (corresponding author), Univ Calif Irvine, Dept Urol, 333 City Blvd West,Suite 1240, Orange, CA 92868 USA. | - |
dc.description.notes | dbarham@hs.uci | - |
local.publisher.place | TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1097/JU.0000000000003071 | - |
dc.identifier.pmid | 36383789 | - |
dc.identifier.isi | 000928267800023 | - |
dc.identifier.eissn | 1527-3792 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Barham, David W.; Hammad, Muhammed; Miller, Jake; Yafi, Faysal A.] Univ Calif Irvine, Dept Urol, Orange, CA USA. | - |
local.description.affiliation | [Pyrgidis, Nikolaos; Hatzichristodoulou, Georgios] Martha Maria Hosp Nuremberg, Dept Urol, Nurnberg, Germany. | - |
local.description.affiliation | [Gross, Martin S.] Dartmouth Hitchcock Med Ctr, Sect Urol, Lebanon, NH USA. | - |
local.description.affiliation | [Swerdloff, Daniel; Simhan, Jay] Fox Chase Canc Ctr, Dept Urol Urol Oncol, Philadelphia, PA USA. | - |
local.description.affiliation | [Alkhayal, Abdullah; Alrabeeah, Khalid A.] King Saud Bin Abdulaziz Univ Hlth Sci, Dept Surg, Div Urol, Riyadh, Saudi Arabia. | - |
local.description.affiliation | [Andrianne, Robert; Sempels, Maxime] Ctr Hosp Univ Liege, Serv Urol, Liege, Belgium. | - |
local.description.affiliation | [Burnett, Arthur L.] Johns Hopkins Univ, Dept Urol, Baltimore, MD USA. | - |
local.description.affiliation | [Gross, Kelli; Hotaling, James M.] Univ Utah, Dept Surg, Div Urol, Salt Lake City, UT USA. | - |
local.description.affiliation | [Hsieh, Tung-Chin] Univ Calif San Diego, Dept Urol, La Jolla, CA USA. | - |
local.description.affiliation | [Modgil, Vaibhav; Pearce, Ian] Manchester Univ NHS Fdn Trust, Manchester Androl Ctr, Manchester, England. | - |
local.description.affiliation | [Lentz, Aaron] Duke Univ, Dept Urol, Durham, NC USA. | - |
local.description.affiliation | [Osmonov, Daniar] Univ Hosp Schleswig Holstein, Dept Urol, Kiel, Germany. | - |
local.description.affiliation | [Park, Sung Hun] Urol Ctr Excellence, Sewum Prosthet Urol, Seoul, South Korea. | - |
local.description.affiliation | [Perito, Paul; Suarez-Sarmiento, Alfredo, Jr.] Perito Urol, Coral Gables, FL USA. | - |
local.description.affiliation | [Sadeghi-Nejad, Hossein] Rutgers New Jersey Med Sch, Div Urol, Newark, NJ USA. | - |
local.description.affiliation | [van Renterghem, Koenraad] Jessa Hosp, Dept Urol, Hasselt, Belgium. | - |
local.description.affiliation | [Warner, J. Nicholas; Ziegelmann, Matthew] Mayo Clin, Dept Urol, Rochester, MN USA. | - |
local.uhasselt.international | yes | - |
item.fulltext | No Fulltext | - |
item.contributor | Barham, David W. | - |
item.contributor | Pyrgidis, Nikolaos | - |
item.contributor | Gross, Martin S. | - |
item.contributor | Hammad, Muhammed | - |
item.contributor | Swerdloff, Daniel | - |
item.contributor | Miller, Jake | - |
item.contributor | Alkhayal, Abdullah | - |
item.contributor | Alrabeeah, Khalid A. | - |
item.contributor | Andrianne, Robert | - |
item.contributor | Burnett, Arthur L. | - |
item.contributor | Gross, Kelli | - |
item.contributor | Hatzichristodoulou, Georgios | - |
item.contributor | Hotaling, James M. | - |
item.contributor | Hsieh, Tung-Chin | - |
item.contributor | Jones, Adam | - |
item.contributor | Jones, James M. | - |
item.contributor | Lentz, Aaron | - |
item.contributor | Levy, Jason | - |
item.contributor | Modgil, Vaibhav | - |
item.contributor | Osmonov, Daniar | - |
item.contributor | Park, Sung Hun | - |
item.contributor | Pearce, Ian | - |
item.contributor | Perito, Paul | - |
item.contributor | Sadeghi-Nejad, Hossein | - |
item.contributor | Sempels, Maxime | - |
item.contributor | Suarez-Sarmiento, Alfredo, Jr. | - |
item.contributor | Simhan, Jay | - |
item.contributor | VAN RENTERGHEM, Koenraad | - |
item.contributor | Warner, J. Nicholas | - |
item.contributor | Ziegelmann, Matthew | - |
item.contributor | Yafi, Faysal A. | - |
item.accessRights | Closed Access | - |
item.fullcitation | Barham, David W.; Pyrgidis, Nikolaos; Gross, Martin S.; Hammad, Muhammed; Swerdloff, Daniel; Miller, Jake; Alkhayal, Abdullah; Alrabeeah, Khalid A.; Andrianne, Robert; Burnett, Arthur L.; Gross, Kelli; Hatzichristodoulou, Georgios; Hotaling, James M.; Hsieh, Tung-Chin; Jones, Adam; Jones, James M.; Lentz, Aaron; Levy, Jason; Modgil, Vaibhav; Osmonov, Daniar; Park, Sung Hun; Pearce, Ian; Perito, Paul; Sadeghi-Nejad, Hossein; Sempels, Maxime; Suarez-Sarmiento, Alfredo, Jr.; Simhan, Jay; VAN RENTERGHEM, Koenraad; Warner, J. Nicholas; Ziegelmann, Matthew & Yafi, Faysal A. (2023) AUA-recommended Antibiotic Prophylaxis for Primary Penile Implantation Results in a Higher, Not Lower, Risk for Postoperative Infection: A Multicenter Analysis. In: JOURNAL OF UROLOGY, 209 (2) , p. 399 -406. | - |
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