Determinants of rehospitalisation, dialysis and death in heart failure: a single-centre retrospective study

Abstract

Introducon Heart failure (HF) is an important cause of hospitalisaons and mortality. Several factors influencing HF outcomes are known, such as age and kidney funcon. The aim of this study was to idenfy which determinants influence rehospitalisaon rate, progression to end-stage renal disease and mortality rate in HF. Methods A single-centre retrospecve study was performed, including parcipants admied in Jessa hospital in Belgium between April 2019 and March 2020 for fluid overload due to HF. All parcipants required an increase or start of diurec treatment, and had a New York Heart Associaon class of 2, 3 or 4. A covariates analysis was executed invesgang eleven determinants. The primary outcome was the composite endpoint of days lost due to cardiovascular rehospitalisaons, dialysis and death in paents with HF. Results 373 paents were included in the database. Mean age was 76.87 years, 198 were male, mean BMI was 27.06 kg/m², median eGFR was 49 mL/min/1.73m². Ischemic heart disease was the most common aeology of HF at 41.82%. 57.91% of parcipants had an LVEF ≤ 50. Both a higher BMI and a higher eGFR correlated with fewer days lost. Other invesgated factors such as diabetes had no significant influence. Conclusion The findings regarding eGFR confirm previous literature that a higher eGFR results in fewer days lost. This study supports the obesity paradox which implies a higher BMI is favourable for readmission rates and mortality aer the inial diagnosis of HF.