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Title: | A Low or High Physical Activity Level Does Not Modulate Prostate Tumor Tissue Protein Synthesis Rates | Authors: | Houben, Lisanne H. P. TUYTTEN, Tom Holwerda, Andrew M. Wisanto, Erika Senden, Joan Wodzig, Will K. W. H. Beelen, Milou Olde Damink, Steven W. M. Beijer, Sandra VAN RENTERGHEM, Koenraad Van Loon, Luc J. C. |
Issue Date: | 2024 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | MEDICINE & SCIENCE IN SPORTS & EXERCISE, 56 (4) , p. 635 -643 | Abstract: | Introduction: Physical activity level has been identified as an important factor in the development and progression of various types of cancer. In this study, we determined the impact of a low versus high physical activity level on skeletal muscle, healthy prostate, and prostate tumor protein synthesis rates in vivo in prostate cancer patients. Methods: Thirty prostate cancer patients (age, 66 +/- 5 yr; body mass index, 27.4 +/- 2.9 kg<middle dot>m(-2)) were randomized to a low (<4000 steps per day, n = 15) or high (>14,000 steps per day, n = 15) physical activity level for 7 d before their scheduled radical prostatectomy. Daily deuterium oxide administration was combined with the collection of plasma, skeletal muscle, nontumorous prostate, and prostate tumor tissue during the surgical procedure to determine tissue protein synthesis rates throughout the intervention period. Results: Daily step counts averaged 3610 +/- 878 and 17,589 +/- 4680 steps in patients subjected to the low and high physical activity levels, respectively (P < 0.001). No differences were observed between tissue protein synthesis rates of skeletal muscle, healthy prostate, or prostate tumor between the low (1.47% +/- 0.21%, 2.74% +/- 0.70%, and 4.76% +/- 1.23% per day, respectively) and high (1.42% +/- 0.16%, 2.64% +/- 0.58%, and 4.72% +/- 0.80% per day, respectively) physical activity group (all P > 0.4). Tissue protein synthesis rates were nearly twofold higher in prostate tumor compared with nontumorous prostate tissue. Conclusions: A short-term high or low physical activity level does not modulate prostate or prostate tumor protein synthesis rates in vivo in prostate cancer patients. More studies on the impact of physical activity level on tumor protein synthesis rates and tumor progression are warranted to understand the potential impact of lifestyle interventions in the prevention and treatment of cancer. | Notes: | Van Loon, LJC (corresponding author), Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Human Biol, Med Ctr, POB 616, NL-6200 MD Maastricht, Netherlands. l.houben@maastrichtuniversity.nl; Tom.Tuytten@jessazh.be; andy.holwerda@maastrichtuniversity.nl; erika.wisanto@jessazh.be; j.senden@maastrichtuniversity.nl; will.wodzig@mumc.nl; milou.beelen@maastrichtuniversity.nl; steven.oldedamink@maastrichtuniversity.nl; s.beijer@iknl.nl; koenraad.vanrenterghem@jessazh.be; l.vanloon@maastrichtuniversity.nl |
Keywords: | EXERCISE;PROSTATE CANCER;TUMOR GROWTH;TUMOR METABOLISM;SKELETAL MUSCLE | Document URI: | http://hdl.handle.net/1942/42922 | ISSN: | 0195-9131 | e-ISSN: | 1530-0315 | DOI: | 10.1249/MSS.0000000000003349 | ISI #: | 001185556800016 | Rights: | 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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