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http://hdl.handle.net/1942/13659
Title: | Maternal mumps antibodies in a cohort of children up to the age of 1 year | Authors: | Leuridan, E. GOEYVAERTS, Nele HENS, Niel Hutse, V. Van Damme, P. |
Issue Date: | 2012 | Source: | European journal of pediatrics, 171(8), p.1167-1173 | Abstract: | The duration of the presence of maternal mumps antibodies in a prospective cohort study is presented. Immunoglobulin G against mumps was portioned with a commercial ELISA test (Euroimmun® anti-mumps Virus AT ELISA, Germany) on samples from 213 mother–child pairs at seven time points between pregnancy and 12 months of age. Non-linear mixed models were used to model maternal antibody decay in infants. The model-based median time to loss of antibodies was 3.6 months. The median child-specific time to loss of antibodies in children of naturally immune women (3.8 months) and children of vaccinated women (2.4 months) differed significantly (p=0.025). The log antibody level of the mother and the log birth weight were correlated with the duration of maternal antibodies in infants (p<0.0001). Conclusion: Children of vaccinated women loose maternal mumps antibodies significantly earlier in life compared to children of naturally infected women. If early administration (<12 months) of the combined measles, mumps, and rubella vaccine is needed, maternal mumps antibodies are not expected to interfere with infant humoral vaccine responses. | Keywords: | Mumps; Maternal antibodies; Vaccination. | Document URI: | http://hdl.handle.net/1942/13659 | ISSN: | 0340-6199 | e-ISSN: | 1432-1076 | DOI: | 10.1007/s00431-012-1691-y | ISI #: | 000306682100004 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2013 |
Appears in Collections: | Research publications |
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