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Title: Maternal mumps antibodies in a cohort of children up to the age of 1 year
Authors: Leuridan, E.
Goeyvaerts, N. 
Hens, N. 
Hutse, V.
Van Damme, P.
Issue Date: 2012
Source: European journal of pediatrics, 171(8), p.1167-1173
Abstract: The duration of the presence of maternal mumps antibodies in a prospective cohort study is presented. Immunoglobulin G against mumps was portioned with a commercial ELISA test (Euroimmun® anti-mumps Virus AT ELISA, Germany) on samples from 213 mother–child pairs at seven time points between pregnancy and 12 months of age. Non-linear mixed models were used to model maternal antibody decay in infants. The model-based median time to loss of antibodies was 3.6 months. The median child-specific time to loss of antibodies in children of naturally immune women (3.8 months) and children of vaccinated women (2.4 months) differed significantly (p=0.025). The log antibody level of the mother and the log birth weight were correlated with the duration of maternal antibodies in infants (p<0.0001). Conclusion: Children of vaccinated women loose maternal mumps antibodies significantly earlier in life compared to children of naturally infected women. If early administration (<12 months) of the combined measles, mumps, and rubella vaccine is needed, maternal mumps antibodies are not expected to interfere with infant humoral vaccine responses.
Keywords: Mumps; Maternal antibodies; Vaccination.
Document URI:
ISSN: 0340-6199
e-ISSN: 1432-1076
DOI: 10.1007/s00431-012-1691-y
ISI #: 000306682100004
Category: A1
Type: Journal Contribution
Validations: ecoom 2013
Appears in Collections:Research publications

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