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http://hdl.handle.net/1942/14302
Title: | Ribosome Dwell Times and the Protein Copy Number Distribution | Authors: | GORISSEN, Mieke VANDERZANDE, Carlo |
Issue Date: | 2012 | Publisher: | SPRINGER | Source: | JOURNAL OF STATISTICAL PHYSICS, 148 (4), p. 627-635 | Abstract: | Translation is the cellular process in which ribosomes make proteins from information encoded on messenger RNA (mRNA). We model translation with an exclusion process taking into account the experimentally determined, non-exponential, waiting time between steps of a ribosome. From numerical simulations using realistic parameter values, we determine the distribution P(E) of the number of proteins E produced by one mRNA. We find that for small E this distribution is not geometric. We present a simplified and analytically solvable model that relates P(E) to the distributions of the times to produce the first E proteins. | Notes: | [Gorissen, Mieke; Vanderzande, Carlo] Hasselt Univ, Fac Sci, B-3590 Diepenbeek, Belgium. [Vanderzande, Carlo] Katholieke Univ Leuven, Inst Theoret Fys, B-3001 Heverlee, Belgium. mieke.gorissen@uhasselt.be; carlo.vanderzande@uhasselt.be | Keywords: | Physics, Mathematical; protein synthesis; TASEP; semi-Markov processes;Protein synthesis; TASEP; Semi-Markov processes | Document URI: | http://hdl.handle.net/1942/14302 | ISSN: | 0022-4715 | e-ISSN: | 1572-9613 | DOI: | 10.1007/s10955-012-0452-7 | ISI #: | 000308648500002 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2013 |
Appears in Collections: | Research publications |
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Ribosome dwell times and the protein copy number distribution.pdf Restricted Access | Published version | 493.04 kB | Adobe PDF | View/Open Request a copy |
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