Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14302
Title: Ribosome Dwell Times and the Protein Copy Number Distribution
Authors: GORISSEN, Mieke 
VANDERZANDE, Carlo 
Issue Date: 2012
Publisher: SPRINGER
Source: JOURNAL OF STATISTICAL PHYSICS, 148 (4), p. 627-635
Abstract: Translation is the cellular process in which ribosomes make proteins from information encoded on messenger RNA (mRNA). We model translation with an exclusion process taking into account the experimentally determined, non-exponential, waiting time between steps of a ribosome. From numerical simulations using realistic parameter values, we determine the distribution P(E) of the number of proteins E produced by one mRNA. We find that for small E this distribution is not geometric. We present a simplified and analytically solvable model that relates P(E) to the distributions of the times to produce the first E proteins.
Notes: [Gorissen, Mieke; Vanderzande, Carlo] Hasselt Univ, Fac Sci, B-3590 Diepenbeek, Belgium. [Vanderzande, Carlo] Katholieke Univ Leuven, Inst Theoret Fys, B-3001 Heverlee, Belgium. mieke.gorissen@uhasselt.be; carlo.vanderzande@uhasselt.be
Keywords: Physics, Mathematical; protein synthesis; TASEP; semi-Markov processes;Protein synthesis; TASEP; Semi-Markov processes
Document URI: http://hdl.handle.net/1942/14302
ISSN: 0022-4715
e-ISSN: 1572-9613
DOI: 10.1007/s10955-012-0452-7
ISI #: 000308648500002
Category: A1
Type: Journal Contribution
Validations: ecoom 2013
Appears in Collections:Research publications

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