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|Title:||Development Of Starch-Based Pellets Via Extrusion/Spheronisation||Authors:||Dukic, A.
|Issue Date:||2006||Publisher:||Elsevier||Source:||EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 66(1). p. 83-94||Abstract:||A modified starch (high-amylose, crystalline and resistant starch) was evaluated as an alternative excipient to microcrystalline cellulose for pellets prepared via extrusion/spheronisation. Theophylline anhydrous (25%, w/w) was used as a model drug. A binder was necessary to obtain an acceptable yield and the addition of sorbitol improved the surface properties of the pellets. A surface response design with three formulation variables (binder, sorbitol and water level) and one process variable (spheronisation speed) was used to optimise the process and to evaluate pellet yield, sphericity (aspect ratio and two-dimensional shape factor, eR), size (mean Feret diameter), friability and disintegration||Keywords:||Extrusion/spheronisation; Pellets; Starch; Sorbitol; NMR; Experimental design||Document URI:||http://hdl.handle.net/1942/1461||ISSN:||0939-6411||e-ISSN:||1873-3441||DOI:||10.1016/j.ejpb.2006.08.015||ISI #:||000245788500011||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2008|
|Appears in Collections:||Research publications|
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