Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1461
Title: Development Of Starch-Based Pellets Via Extrusion/Spheronisation
Authors: Dukic, A.
MENS, Raoul 
ADRIAENSENS, Peter 
Foreman, P.
GELAN, Jan 
Remon, J.P.
Vervaet, C.
Issue Date: 2006
Publisher: Elsevier
Source: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 66(1). p. 83-94
Abstract: A modified starch (high-amylose, crystalline and resistant starch) was evaluated as an alternative excipient to microcrystalline cellulose for pellets prepared via extrusion/spheronisation. Theophylline anhydrous (25%, w/w) was used as a model drug. A binder was necessary to obtain an acceptable yield and the addition of sorbitol improved the surface properties of the pellets. A surface response design with three formulation variables (binder, sorbitol and water level) and one process variable (spheronisation speed) was used to optimise the process and to evaluate pellet yield, sphericity (aspect ratio and two-dimensional shape factor, eR), size (mean Feret diameter), friability and disintegration
Keywords: Extrusion/spheronisation; Pellets; Starch; Sorbitol; NMR; Experimental design
Document URI: http://hdl.handle.net/1942/1461
ISSN: 0939-6411
e-ISSN: 1873-3441
DOI: 10.1016/j.ejpb.2006.08.015
ISI #: 000245788500011
Category: A1
Type: Journal Contribution
Validations: ecoom 2008
Appears in Collections:Research publications

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