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Title: A case of HPV-53-related cervical cancer in an elderly patient
Authors: Lieveld, Marusya
PADALKO, Elizaveta 
Praet, Marleen
Broeck, Davy Vanden
Issue Date: 2014
Source: Clinical Interventions in Aging, 9, p. 1933-1934
Abstract: Zappacosta et al1 recently published a case report concerning a human papillomavirus (HPV)-positive invasive cervical cancer in a 79-year-old women who had a history of normal Pap smears. In this article, Anyplex II HPV28 (Seegene) is used for HPV genotyping of formalin-fixed paraffin embedded (FFPE) tissue, liquid based cytology (LBC) specimens and urine samples. It is suggested that HPV53 is present exclusively in the cervical cancer cells, lymph node metastases, and atypical urinary cells of one single case while the surrounding CIN2+ tissue revealed ten different HPV strains. Unfortunately, the HPV genotype results for lymph nodes and urinary cells are not presented while these results underline the potential role of HPV53 in oncogenesis. Moreover, it is generally accepted that one lesion is caused by one HPV infection, detection of multiple HPV types thus indicates the presence of multiple infections,2 suggesting that this patient may have several lesions.
Notes: [Lieveld, Marusya; Broeck, Davy Vanden] Ghent Univ Hosp, Dept Urogynaecol, Ghent, Belgium. [Padalko, Elizaveta] Ghent Univ Hosp, Dept Clin Chem Microbiol & Immunol, Ghent, Belgium. [Padalko, Elizaveta] Hasselt Univ, Sch Life Sci, Diepenbeek, Belgium. [Praet, Marleen] Ghent Univ Hosp, N Goormaghtigh Inst Pathol, Ghent, Belgium.
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e-ISSN: 1178-1998
DOI: 10.2147/CIA.S71262
ISI #: 000344921300001
Rights: © 2014 Lieveld et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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