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http://hdl.handle.net/1942/19071
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DC Field | Value | Language |
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dc.contributor.author | JANSSENS, Kris | - |
dc.contributor.author | MAHESHWARI, Anurag | - |
dc.contributor.author | Van den Haute, C. | - |
dc.contributor.author | Baekelandt, Veerle | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.contributor.author | SLAETS, Leen | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.date.accessioned | 2015-09-02T10:08:50Z | - |
dc.date.available | 2015-09-02T10:08:50Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | GLIA, 63 (10), p. 1729-1737 | - |
dc.identifier.issn | 0894-1491 | - |
dc.identifier.uri | http://hdl.handle.net/1942/19071 | - |
dc.description.abstract | Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system (CNS), in which destruction of myelin sheaths leads to disturbed axonal conduction. Available MS therapies modulate the immune response, but are unable to prevent neurological decline. Therefore, great efforts are made to develop therapies that limit demyelination and axonal degeneration. Oncostatin M (OSM), a member of the interleukin (IL)-6 cytokine family, is produced in demyelinating lesions of MS patients and stimulates neuronal survival. In this study, we reveal that the OSM receptor (OSMR) was robustly upregulated on microglia/macrophages and astrocytes in the cuprizone-induced demyelination model. While OSMR deficiency led to aggravated demyelination, CNS-targeted OSM treatment largely prevented demyelination. OSM treatment increased IL-4 expression and induced polarization of myeloid cells towards an anti-inflammatory M2 phenotype in vivo. This study reveals a previously uncharacterized and protective role for OSM during demyelination, and indicates that OSM is a promising therapeutic candidate to limit CNS damage in demyelinating diseases including MS | - |
dc.description.sponsorship | Grant sponsor: Flemish Fund for Scientific Research (FWO Vlaanderen); Grant number: G04441N; Grant sponsor: Inter-university Attraction Poles; Grant number: IUAP-P7-39; Grant sponsor: European FP7project; Grant number: HEALTH-F2-2011-278850 (INMiND); Grant sponsor: Belgian MS-Liga; Methusalem NEURONET; BOF-UHasselt | - |
dc.language.iso | en | - |
dc.rights | © 2015 Wiley Periodicals, Inc. | - |
dc.subject.other | multiple sclerosis; demyelination; oncostatin M; microglia | - |
dc.title | Oncostatin M protects against demyelination by inducing a protective microglial phenotype. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1737 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 1729 | - |
dc.identifier.volume | 63 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Address correspondence to Niels Hellings, Agoralaan building C, 3590 Diepenbeek, Belgium. E-mail: niels.hellings@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/glia.22840 | - |
dc.identifier.isi | 000359606700004 | - |
item.fullcitation | JANSSENS, Kris; MAHESHWARI, Anurag; Van den Haute, C.; Baekelandt, Veerle; STINISSEN, Piet; HENDRIKS, Jerome; SLAETS, Leen & HELLINGS, Niels (2015) Oncostatin M protects against demyelination by inducing a protective microglial phenotype.. In: GLIA, 63 (10), p. 1729-1737. | - |
item.contributor | JANSSENS, Kris | - |
item.contributor | MAHESHWARI, Anurag | - |
item.contributor | Van den Haute, C. | - |
item.contributor | Baekelandt, Veerle | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | HENDRIKS, Jerome | - |
item.contributor | SLAETS, Leen | - |
item.contributor | HELLINGS, Niels | - |
item.validation | ecoom 2016 | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0894-1491 | - |
crisitem.journal.eissn | 1098-1136 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Janssens_et_al-2015-Glia.pdf Restricted Access | Published version | 1.07 MB | Adobe PDF | View/Open Request a copy |
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