Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19131
Title: Humoral autoimmunity: A failure of regulatory T cells?
Authors: DHAEZE, Tessa 
STINISSEN, Piet 
Liston, Adrian
HELLINGS, Niels 
Issue Date: 2015
Publisher: ELSEVIER SCIENCE BV
Source: AUTOIMMUNITY REVIEWS, 14 (8), p. 735-741
Abstract: Regulatory T cells (Tregs) are essential in maintaining tolerance to self. Several lines of evidence indicate that Tregs are functionally impaired in a variety of autoimmune diseases, leading to inefficient regulation of autoimmune T cells. Recent findings also suggest that Tregs are essential in controlling autoreactive B cells. The recently identified follicular regulatory T cell subset (T-FR) is thought to regulate the production of autoantibodies in the germinal center (GC) response. Here we provide an update on the role of Tregs in controlling the GC response, and whether defective control over B cell tolerance contributes to autoimmunity. (C) 2015 Elsevier B.V. All rights reserved.
Notes: [Dhaeze, Tessa; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Onderzoeksinst, Diepenbeek, Belgium. [Dhaeze, Tessa; Stinissen, Piet; Hellings, Niels] Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [Liston, Adrian] VIB, Autoimmune Genet Lab, Leuven, Belgium. [Liston, Adrian] Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium.
Keywords: regulatory T cells; humoral autoimmune disease; follicular T cells; B cells; germinal center response; circulating follicular regulatory T cells;Regulatory T cells; Humoral autoimmune disease; Follicular T cells; B cells; Germinal center response; Circulating follicular regulatory T cells
Document URI: http://hdl.handle.net/1942/19131
ISSN: 1568-9972
e-ISSN: 1873-0183
DOI: 10.1016/j.autrev.2015.04.006
ISI #: 000357243600011
Rights: © 2015 Elsevier B.V. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2016
Appears in Collections:Research publications

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