Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/19131
Title: | Humoral autoimmunity: A failure of regulatory T cells? | Authors: | DHAEZE, Tessa STINISSEN, Piet Liston, Adrian HELLINGS, Niels |
Issue Date: | 2015 | Publisher: | ELSEVIER SCIENCE BV | Source: | AUTOIMMUNITY REVIEWS, 14 (8), p. 735-741 | Abstract: | Regulatory T cells (Tregs) are essential in maintaining tolerance to self. Several lines of evidence indicate that Tregs are functionally impaired in a variety of autoimmune diseases, leading to inefficient regulation of autoimmune T cells. Recent findings also suggest that Tregs are essential in controlling autoreactive B cells. The recently identified follicular regulatory T cell subset (T-FR) is thought to regulate the production of autoantibodies in the germinal center (GC) response. Here we provide an update on the role of Tregs in controlling the GC response, and whether defective control over B cell tolerance contributes to autoimmunity. (C) 2015 Elsevier B.V. All rights reserved. | Notes: | [Dhaeze, Tessa; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Onderzoeksinst, Diepenbeek, Belgium. [Dhaeze, Tessa; Stinissen, Piet; Hellings, Niels] Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [Liston, Adrian] VIB, Autoimmune Genet Lab, Leuven, Belgium. [Liston, Adrian] Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium. | Keywords: | regulatory T cells; humoral autoimmune disease; follicular T cells; B cells; germinal center response; circulating follicular regulatory T cells;Regulatory T cells; Humoral autoimmune disease; Follicular T cells; B cells; Germinal center response; Circulating follicular regulatory T cells | Document URI: | http://hdl.handle.net/1942/19131 | ISSN: | 1568-9972 | e-ISSN: | 1873-0183 | DOI: | 10.1016/j.autrev.2015.04.006 | ISI #: | 000357243600011 | Rights: | © 2015 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
dhaeze 1.pdf Restricted Access | Published version | 746.97 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
35
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
35
checked on Oct 14, 2024
Page view(s)
48
checked on May 19, 2022
Download(s)
44
checked on May 19, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.