Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22909
Title: Stem Cell-Based Therapies for Ischemic Stroke: Preclinical Results and the Potential of Imaging-Assisted Evaluation of Donor Cell Fate and Mechanisms of Brain Regeneration
Authors: GERVOIS, Pascal 
WOLFS, Esther 
RATAJCZAK, Jessica 
DILLEN, Yorg 
VANGANSEWINKEL, Tim 
HILKENS, Petra 
BRONCKAERS, Annelies 
LAMBRICHTS, Ivo 
STRUYS, Tom 
Issue Date: 2016
Source: MEDICINAL RESEARCH REVIEWS, 36(6), p. 1080-1126
Abstract: Stroke is the second most common cause of death and is a major cause of permanent disability. Given the current demographic trend of an ageing population and associated increased risk, the prevalence of and socioeconomic burden caused by stroke will continue to rise. Current therapies are unable to sufficiently ameliorate the disease outcome and are not applicable to all patients. Therefore, strategies such as cell-based therapies with mesenchymal stem cell (MSC) or induced pluripotent stem cell (iPSC) pave the way for new treatment options for stroke. These cells showed great preclinical promise despite the fact that the precise mechanism of action and the optimal administration route are unknown. To gain dynamic insights into the underlying repair processes after stem cell engraftment, noninvasive imaging modalities were developed to provide detailed spatial and functional information on the donor cell fate and host microenvironment. This review will focus on MSCs and iPSCs as types of widely used stem cell sources in current (bio)medical research and compare their efficacy and potential to ameliorate the disease outcome in animal stroke models. In addition, novel noninvasive imaging strategies allowing temporospatial in vivo tracking of transplanted cells and coinciding evaluation of neuronal repair following stroke will be discussed.
Notes: Struys, T (reprint author), Hasselt Univ, Biomed Res Inst, Morphol Res Grp, Campus Diepenbeek, Diepenbeek, Belgium. tom.struys@uhasselt.be
Keywords: ischemic stroke; mesenchymal stem cells; induced pluripotent stem cells; mechanisms of stem cell therapy; noninvasive imaging
Document URI: http://hdl.handle.net/1942/22909
ISSN: 0198-6325
e-ISSN: 1098-1128
DOI: 10.1002/med.21400
ISI #: 000386803100003
Rights: (C) 2016 Wiley Periodicals, Inc.
Category: A1
Type: Journal Contribution
Validations: ecoom 2017
Appears in Collections:Research publications

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