Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/22909
Title: | Stem Cell-Based Therapies for Ischemic Stroke: Preclinical Results and the Potential of Imaging-Assisted Evaluation of Donor Cell Fate and Mechanisms of Brain Regeneration | Authors: | GERVOIS, Pascal WOLFS, Esther RATAJCZAK, Jessica DILLEN, Yorg VANGANSEWINKEL, Tim HILKENS, Petra BRONCKAERS, Annelies LAMBRICHTS, Ivo STRUYS, Tom |
Issue Date: | 2016 | Source: | MEDICINAL RESEARCH REVIEWS, 36(6), p. 1080-1126 | Abstract: | Stroke is the second most common cause of death and is a major cause of permanent disability. Given the current demographic trend of an ageing population and associated increased risk, the prevalence of and socioeconomic burden caused by stroke will continue to rise. Current therapies are unable to sufficiently ameliorate the disease outcome and are not applicable to all patients. Therefore, strategies such as cell-based therapies with mesenchymal stem cell (MSC) or induced pluripotent stem cell (iPSC) pave the way for new treatment options for stroke. These cells showed great preclinical promise despite the fact that the precise mechanism of action and the optimal administration route are unknown. To gain dynamic insights into the underlying repair processes after stem cell engraftment, noninvasive imaging modalities were developed to provide detailed spatial and functional information on the donor cell fate and host microenvironment. This review will focus on MSCs and iPSCs as types of widely used stem cell sources in current (bio)medical research and compare their efficacy and potential to ameliorate the disease outcome in animal stroke models. In addition, novel noninvasive imaging strategies allowing temporospatial in vivo tracking of transplanted cells and coinciding evaluation of neuronal repair following stroke will be discussed. | Notes: | Struys, T (reprint author), Hasselt Univ, Biomed Res Inst, Morphol Res Grp, Campus Diepenbeek, Diepenbeek, Belgium. tom.struys@uhasselt.be | Keywords: | ischemic stroke; mesenchymal stem cells; induced pluripotent stem cells; mechanisms of stem cell therapy; noninvasive imaging | Document URI: | http://hdl.handle.net/1942/22909 | ISSN: | 0198-6325 | e-ISSN: | 1098-1128 | DOI: | 10.1002/med.21400 | ISI #: | 000386803100003 | Rights: | (C) 2016 Wiley Periodicals, Inc. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Gervois_et_al-2016-Medicinal_Research_Reviews.pdf Restricted Access | Published version | 707.76 kB | Adobe PDF | View/Open Request a copy |
Reviewartikel proofs.pdf | Peer-reviewed author version | 789.85 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
28
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
55
checked on Oct 13, 2024
Page view(s)
78
checked on Aug 31, 2022
Download(s)
598
checked on Aug 31, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.