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dc.contributor.authorMesquita, Rafael-
dc.contributor.authorSpina, Gabriele-
dc.contributor.authorPitta, Fabio-
dc.contributor.authorDonaire-Gonzalez, David-
dc.contributor.authorDeering, Brenda M.-
dc.contributor.authorPatel, Mehul S.-
dc.contributor.authorMitchell, Katy E.-
dc.contributor.authorAlison, Jennifer-
dc.contributor.authorvan Gestel, Arnoldus J. R.-
dc.contributor.authorZogg, Stefanie-
dc.contributor.authorGagnon, Philippe-
dc.contributor.authorAbascal-Bolado, Beatriz-
dc.contributor.authorVagaggini, Barbara-
dc.contributor.authorGarcia-Aymerich, Judith-
dc.contributor.authorJenkins, Sue C.-
dc.contributor.authorRomme, Elisabeth A. P. M.-
dc.contributor.authorKon, Samantha S. C.-
dc.contributor.authorAlbert, Paul S.-
dc.contributor.authorWaschki, Benjamin-
dc.contributor.authorShrikrishna, Dinesh-
dc.contributor.authorSingh, Sally J.-
dc.contributor.authorHopkinson, Nicholas S.-
dc.contributor.authorMiedinger, David-
dc.contributor.authorBenzo, Roberto P.-
dc.contributor.authorMaltais, Francois-
dc.contributor.authorPaggiaro, Pierluigi-
dc.contributor.authorMcKeough, Zoe J.-
dc.contributor.authorPolkey, Michael I.-
dc.contributor.authorHill, Kylie-
dc.contributor.authorMan, William D-C-
dc.contributor.authorClarenbach, Christian F.-
dc.contributor.authorHernandes, Nidia A.-
dc.contributor.authorSavi, Daniela-
dc.contributor.authorWootton, Sally-
dc.contributor.authorFurlanetto, Karina C.-
dc.contributor.authorNg, Li W. Cindy-
dc.contributor.authorVaes, Anouk W.-
dc.contributor.authorJenkins, Christine-
dc.contributor.authorEastwood, Peter R.-
dc.contributor.authorJarreta, Diana-
dc.contributor.authorKirsten, Anne-
dc.contributor.authorBrooks, Dina-
dc.contributor.authorHillman, David R.-
dc.contributor.authorSant'Anna, Thais-
dc.contributor.authorMeijer, Kenneth-
dc.contributor.authorDurr, Selina-
dc.contributor.authorRutten, Erica P. A.-
dc.contributor.authorKohler, Malcolm-
dc.contributor.authorProbst, Vanessa S.-
dc.contributor.authorTal-Singer, Ruth-
dc.contributor.authorGarcia Gil, Esther-
dc.contributor.authorden Brinker, Albertus C.-
dc.contributor.authorLeuppi, Jorg D.-
dc.contributor.authorCalverley, Peter M. A.-
dc.contributor.authorSmeenk, Frank W. J. M.-
dc.contributor.authorCostello, Richard W.-
dc.contributor.authorGramm, Marco-
dc.contributor.authorGoldstein, Roger-
dc.contributor.authorGroenen, Miriam T. J.-
dc.contributor.authorMagnussen, Helgo-
dc.contributor.authorWouters, Emiel F. M.-
dc.contributor.authorZuWallack, Richard L.-
dc.contributor.authorAmft, Oliver-
dc.contributor.authorWatz, Henrik-
dc.contributor.authorSPRUIT, Martijn A.-
dc.identifier.citationCHRONIC RESPIRATORY DISEASE, 14(3), p. 256-269-
dc.description.abstractWe described physical activity measures and hourly patterns in patients with chronic obstructive pulmonary disease (COPD) after stratification for generic and COPD-specific characteristics and, based on multiple physical activity measures, we identified clusters of patients. In total, 1001 patients with COPD (65% men; age, 67 years; forced expiratory volume in the first second [FEV1], 49% predicted) were studied cross-sectionally. Demographics, anthropometrics, lung function and clinical data were assessed. Daily physical activity measures and hourly patterns were analysed based on data from a multisensor armband. Principal component analysis (PCA) and cluster analysis were applied to physical activity measures to identify clusters. Age, body mass index (BMI), dyspnoea grade and ADO index (including age, dyspnoea and airflow obstruction) were associated with physical activity measures and hourly patterns. Five clusters were identified based on three PCA components, which accounted for 60% of variance of the data. Importantly, couch potatoes (i.e. the most inactive cluster) were characterised by higher BMI, lower FEV1, worse dyspnoea and higher ADO index compared to other clusters (p < 0.05 for all). Daily physical activity measures and hourly patterns are heterogeneous in COPD. Clusters of patients were identified solely based on physical activity data. These findings may be useful to develop interventions aiming to promote physical activity in COPD.-
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: RM is supported by the National Council of Scientific and Technological Development (CNPq), Brazil (246704/2012-8). DB holds a Canada Research Chair, Canada. SSCK was funded by the Medical Research Council, UK. WD-CM was funded by the Medical Research Council, UK, and the National Institute for Health Research, UK. MSP was supported by an unrestricted research grant from Astra Zeneca. KCF is supported by the Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil. SZ, DM, SD and JDL were supported by the following foundations: 'Gottfried und Julia Bangerter-Rhyner-Stiftung', 'Freiwillige Akademische Gesellschaft Basel' and 'Forschungsfonds der Universitat Basel', Switzerland. DS was supported by GSK and by the Medical Research Council, UK (G0701628). FP is supported by CNPq, Brazil. PRE was supported by an NHMRC Research Fellowship, Australia (1042341). MIP's contribution to this manuscript was funded by the NIHR Respiratory Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College, UK. EFMW was supported by Point-One funding from AgentschapNL, Dutch Ministry of Economic affairs, the Netherlands. AWV was supported by 'Stichting de Weijerhorst' and Point-One funding from AgentschapNL, Dutch Ministry of Economic affairs, Netherlands. MAS was supported by Point-One funding from AgentschapNL, Dutch Ministry of Economic affairs, the Netherlands. Part of the data was sponsored by GlaxoSmithKline (data from the ECLIPSE cohort sub-study). Data from Ireland was supported by Beaumont Foundation, Ireland and SwordMedical Ltd, Ireland. The Australian sites were supported by a National Health and Medical Research Grant, Australia (grant no.: 570814). Part of the data collection in the UK (data from Leicester) was supported by the National Institute for Health Research (NIHR) Leicestershire, Northamptonshire and Rutland Collaboration for Leadership in Applied Health Research and Care and took place at University Hospitals of Leicester NHS Trust, UK, and by the NIHR Leicester Respiratory Biomedical Research Unit, UK. Data from the PAC-COPD study was funded by grants from the following Spanish institutions: Fondo de Investigacion Sanitaria, Ministry of Health (FIS PI020541); Agencia d'Avaluacio de Tecnologia i Recerca Mediques, Catalonia Government (AATRM 035/20/02); Spanish Society of Pneumology and Thoracic Surgery (SEPAR 2002/137); Catalan Foundation of Pneumology (FUCAP 2003 Beca Maria Rava); Red RESPIRA (RTIC C03/11); Red RCESP (RTIC C03/09), Fondo de Investigacion Sanitaria (PI052486); Fondo de Investigacion Sanitaria (PI052302); Fundacio La Marato de TV3 (No. 041110); and DURSI (2005SGR00392); and by unrestricted educational grants from Novartis Farmaceutica and AstraZeneca Farmaceutica.-
dc.rightsCreative Commons CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 3.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (
dc.subject.otherChronic obstructive pulmonary disease; physical activity; outcome assessment (healthcare); principal component analysis; cluster analysis-
dc.subject.otherchronic obstructive pulmonary disease; physical activity; outcome assessment (healthcare); principal component analysis; cluster analysis-
dc.titlePhysical activity patterns and clusters in 1001 patients with COPD-
dc.typeJournal Contribution-
dc.description.notes[Mesquita, Rafael; Vaes, Anouk W.; Rutten, Erica P. A.; Groenen, Miriam T. J.; Wouters, Emiel F. M.; Spruit, Martijn A.] CIRO, Dept Res & Educ, Hornerheide 1, NL-6085 NM Horn, Netherlands. [Mesquita, Rafael; Wouters, Emiel F. M.; Spruit, Martijn A.] MUMC, Dept Resp Med, Maastricht, Netherlands. [Spina, Gabriele; Amft, Oliver] Tech Univ Eindhoven, Dept Signal Proc Syst, Eindhoven, Netherlands. [Spina, Gabriele; den Brinker, Albertus C.] Philips Res, Smart Profess Spaces Grp, Eindhoven, Netherlands. [Pitta, Fabio; Hernandes, Nidia A.; Furlanetto, Karina C.; Sant'Anna, Thais; Probst, Vanessa S.] State Univ Londrina UEL, Dept Physiotherapy, Lab Res Resp Physiotherapy, Londrina, Brazil. [Donaire-Gonzalez, David; Garcia-Aymerich, Judith] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Donaire-Gonzalez, David; Garcia-Aymerich, Judith] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain. [Deering, Brenda M.; Costello, Richard W.] Beaumont Hosp, Dept Resp Med, Dublin, Ireland. [Patel, Mehul S.; Kon, Samantha S. C.; Shrikrishna, Dinesh; Hopkinson, Nicholas S.; Polkey, Michael I.; Man, William D-C] Royal Brompton & Harefield NHS Fdn Trust, NIHR Resp Biomed Res Unit, London, England. [Patel, Mehul S.; Kon, Samantha S. C.; Shrikrishna, Dinesh; Hopkinson, Nicholas S.; Polkey, Michael I.; Man, William D-C] Imperial Coll, London, England. [Mitchell, Katy E.; Singh, Sally J.] Univ Hosp, NIHR EM CLAHRC Ctr Exercise & Rehabil Sci, Leicester, Leics, England. [Alison, Jennifer; McKeough, Zoe J.; Wootton, Sally] Univ Sydney, Clin & Rehabil Sci, Sydney, NSW, Australia. [Alison, Jennifer] Royal Prince Alfred Hosp, Physiotherapy Dept, Sydney, NSW, Australia. [van Gestel, Arnoldus J. R.; Clarenbach, Christian F.; Kohler, Malcolm] Univ Hosp Zurich, Div Pulm, Zurich, Switzerland. [Zogg, Stefanie; Miedinger, David; Durr, Selina; Leuppi, Jorg D.] Cantonal Hosp Baselland, Med Univ Clin, Liestal, Switzerland. [Zogg, Stefanie; Miedinger, David; Durr, Selina; Leuppi, Jorg D.] Univ Basel, Fac Med, Basel, Switzerland. [Gagnon, Philippe; Maltais, Francois] Univ Laval, Ctr Rech, Inst Univ Cardiol & Pneumol Quebec, 2725 Chemin Ste Foy Quebec, Quebec City, PQ, Canada. [Abascal-Bolado, Beatriz] Hosp Univ Marques de Valdecilla, Div Pulm, IFIMAV, Santander, Spain. [Abascal-Bolado, Beatriz; Benzo, Roberto P.] Mayo Clin, Mindful Breathing Lab, Rochester, MN USA. [Vagaggini, Barbara; Paggiaro, Pierluigi] Univ Pisa, Cardiothorac & Vasc Dept, Pisa, Italy. [Garcia-Aymerich, Judith] UPF, Barcelona, Spain. [Jenkins, Sue C.; Hill, Kylie; Ng, Li W. Cindy] Curtin Univ, Sch Physiotherapy & Exercise Sci, Perth, WA, Australia. [Romme, Elisabeth A. P. M.; Smeenk, Frank W. J. M.] Catharina Hosp, Dept Resp Med, Eindhoven, Netherlands. [Albert, Paul S.; Calverley, Peter M. A.] Aintree Univ Hosp NHS Fdn Trust, Sch Ageing & Chron Dis, Liverpool, Merseyside, England. [Waschki, Benjamin; Kirsten, Anne; Gramm, Marco; Magnussen, Helgo; Watz, Henrik] German Ctr Lung Res, Airway Res Ctr North, Pulm Res Inst, LungClin Grosshansdorf, Grosshansdorf, Germany. [Shrikrishna, Dinesh] Taunton & Somerset NHS Fdn Trust, Musgrove Pk Hosp, Taunton, Somerset, England. [Savi, Daniela] Sapienza Univ Rome, Cyst Fibrosis Ctr, Dept Pediat & Pediat Neurol, Rome, Italy. [Vaes, Anouk W.] Flemish Inst Technol Res VITO, Environm Risk & Hlth, Mol, Belgium. [Jenkins, Christine] Univ Sydney, Woolcock Inst Med Res, Camperdown, NSW, Australia. [Eastwood, Peter R.; Hillman, David R.] Sir Charles Gairdner Hosp, Dept Pulm Physiol, Perth, WA, Australia. [Jarreta, Diana; Garcia Gil, Esther] AstraZeneca, Barcelona, Spain. [Brooks, Dina; Goldstein, Roger] Univ Toronto, West Pk Healthcare Ctr, Resp Med, Toronto, ON, Canada. [Brooks, Dina; Goldstein, Roger] Univ Toronto, Fac Med, Toronto, ON, Canada. [Meijer, Kenneth] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Human Movement Sci, Maastricht, Netherlands. [Probst, Vanessa S.] Univ North Parana UNOPAR, Ctr Res Hlth Sci, Londrina, Brazil. [Tal-Singer, Ruth] GlaxoSmithKline R&D, King Of Prussia, PA USA. [ZuWallack, Richard L.] St Francis Hosp & Med Ctr, Dept Pulm & Crit Care, Hartford, CT USA. [Amft, Oliver] Univ Passau, ACTLab Grp, Chair Sensor Technol, Passau, Germany. [Spruit, Martijn A.] Hasselt Univ, BIOMED Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium.-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.validationecoom 2018-
item.fullcitationMesquita, Rafael; Spina, Gabriele; Pitta, Fabio; Donaire-Gonzalez, David; Deering, Brenda M.; Patel, Mehul S.; Mitchell, Katy E.; Alison, Jennifer; van Gestel, Arnoldus J. R.; Zogg, Stefanie; Gagnon, Philippe; Abascal-Bolado, Beatriz; Vagaggini, Barbara; Garcia-Aymerich, Judith; Jenkins, Sue C.; Romme, Elisabeth A. P. M.; Kon, Samantha S. C.; Albert, Paul S.; Waschki, Benjamin; Shrikrishna, Dinesh; Singh, Sally J.; Hopkinson, Nicholas S.; Miedinger, David; Benzo, Roberto P.; Maltais, Francois; Paggiaro, Pierluigi; McKeough, Zoe J.; Polkey, Michael I.; Hill, Kylie; Man, William D-C; Clarenbach, Christian F.; Hernandes, Nidia A.; Savi, Daniela; Wootton, Sally; Furlanetto, Karina C.; Ng, Li W. Cindy; Vaes, Anouk W.; Jenkins, Christine; Eastwood, Peter R.; Jarreta, Diana; Kirsten, Anne; Brooks, Dina; Hillman, David R.; Sant'Anna, Thais; Meijer, Kenneth; Durr, Selina; Rutten, Erica P. A.; Kohler, Malcolm; Probst, Vanessa S.; Tal-Singer, Ruth; Garcia Gil, Esther; den Brinker, Albertus C.; Leuppi, Jorg D.; Calverley, Peter M. A.; Smeenk, Frank W. J. M.; Costello, Richard W.; Gramm, Marco; Goldstein, Roger; Groenen, Miriam T. J.; Magnussen, Helgo; Wouters, Emiel F. M.; ZuWallack, Richard L.; Amft, Oliver; Watz, Henrik & SPRUIT, Martijn A. (2017) Physical activity patterns and clusters in 1001 patients with COPD. In: CHRONIC RESPIRATORY DISEASE, 14(3), p. 256-269.-
item.contributorHillman, David R.-
item.contributorJenkins, Christine-
item.contributorSpina, Gabriele-
item.contributorRutten, Erica P. A.-
item.contributorMcKeough, Zoe J.-
item.contributorSmeenk, Frank W. J. M.-
item.contributorSavi, Daniela-
item.contributorTal-Singer, Ruth-
item.contributorWootton, Sally-
item.contributorJarreta, Diana-
item.contributorWatz, Henrik-
item.contributorWouters, Emiel F. M.-
item.contributorZuWallack, Richard L.-
item.contributorKohler, Malcolm-
item.contributorGarcia-Aymerich, Judith-
item.contributorLeuppi, Jorg D.-
item.contributorCostello, Richard W.-
item.contributorAlison, Jennifer-
item.contributorMagnussen, Helgo-
item.contributorHill, Kylie-
item.contributorMaltais, Francois-
item.contributorRomme, Elisabeth A. P. M.-
item.contributorMesquita, Rafael-
item.contributorShrikrishna, Dinesh-
item.contributorAbascal-Bolado, Beatriz-
item.contributorKon, Samantha S. C.-
item.contributorAlbert, Paul S.-
item.contributorKirsten, Anne-
item.contributorProbst, Vanessa S.-
item.contributorGarcia Gil, Esther-
item.contributorHernandes, Nidia A.-
item.contributorSingh, Sally J.-
item.contributorPaggiaro, Pierluigi-
item.contributorvan Gestel, Arnoldus J. R.-
item.contributorFurlanetto, Karina C.-
item.contributorGramm, Marco-
item.contributorEastwood, Peter R.-
item.contributorBrooks, Dina-
item.contributorBenzo, Roberto P.-
item.contributorDeering, Brenda M.-
item.contributorden Brinker, Albertus C.-
item.contributorJenkins, Sue C.-
item.contributorZogg, Stefanie-
item.contributorGoldstein, Roger-
item.contributorSant'Anna, Thais-
item.contributorVaes, Anouk W.-
item.contributorVagaggini, Barbara-
item.contributorSPRUIT, Martijn A.-
item.contributorPatel, Mehul S.-
item.contributorMeijer, Kenneth-
item.contributorMiedinger, David-
item.contributorDurr, Selina-
item.contributorNg, Li W. Cindy-
item.contributorDonaire-Gonzalez, David-
item.contributorGroenen, Miriam T. J.-
item.contributorHopkinson, Nicholas S.-
item.contributorGagnon, Philippe-
item.contributorPolkey, Michael I.-
item.contributorMan, William D-C-
item.contributorCalverley, Peter M. A.-
item.contributorMitchell, Katy E.-
item.contributorPitta, Fabio-
item.contributorWaschki, Benjamin-
item.contributorAmft, Oliver-
item.contributorClarenbach, Christian F.-
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