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http://hdl.handle.net/1942/32895
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DC Field | Value | Language |
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dc.contributor.author | Osella, Silvio | - |
dc.contributor.author | Paloncyova, Marketa | - |
dc.contributor.author | Sahi, Maryam | - |
dc.contributor.author | KNIPPENBERG, Stefan | - |
dc.date.accessioned | 2020-12-11T14:18:32Z | - |
dc.date.available | 2020-12-11T14:18:32Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-12-11T14:01:34Z | - |
dc.identifier.citation | MOLECULES, 25 (18) (Art N° 4264) | - |
dc.identifier.uri | http://hdl.handle.net/1942/32895 | - |
dc.description.abstract | The fluorescent molecule diphenylhexatriene (DPH) has been often used in combination with fluorescence anisotropy measurements, yet little is known regarding the non-linear optical properties. In the current work, we focus on them and extend the application to fluorescence, while paying attention to the conformational versatility of DPH when it is embedded in different membrane phases. Extensive hybrid quantum mechanics/molecular mechanics calculations were performed to investigate the influence of the phase- and temperature-dependent lipid environment on the probe. Already, the transition dipole moments and one-photon absorption spectra obtained in the liquid ordered mixture of sphingomyelin (SM)-cholesterol (Chol) (2:1) differ largely from the ones calculated in the liquid disordered DOPC and solid gel DPPC membranes. Throughout the work, the molecular conformation in SM:Chol is found to differ from the other environments. The two-photon absorption spectra and the ones obtained by hyper-Rayleigh scattering depend strongly on the environment. Finally, a stringent comparison of the fluorescence anisotropy decay and the fluorescence lifetime confirm the use of DPH to gain information upon the surrounding lipids and lipid phases. DPH might thus open the possibility to detect and analyze different biological environments based on its absorption and emission properties. | - |
dc.description.sponsorship | S.O. is grateful to the National Science Centre, Poland, for the Grant UMO-2018/31/D/ST4/01475. M.P. acknowledges the support from ERDF/ESF with Project no. CZ.02.1.01/0.0/0.0/16_019/0000754 and S.K. thanks the Czech Science Foundation for the financial aid from the Grant 17-21122S. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | conformationally versatile molecules | - |
dc.subject.other | QM | - |
dc.subject.other | MM | - |
dc.subject.other | absorption | - |
dc.subject.other | photoselection | - |
dc.subject.other | fluorescence decay | - |
dc.subject.other | fluorescence anisotropy | - |
dc.subject.other | hyper-Rayleigh scattering | - |
dc.subject.other | two-photon absorption | - |
dc.title | Influence of Membrane Phase on the Optical Properties of DPH | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 18 | - |
dc.identifier.volume | 25 | - |
local.format.pages | 20 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Osella, S (corresponding author), Univ Warsaw, Chem & Biol Syst Simulat Lab, Ctr New Technol, Banacha 2c, PL-02097 Warsaw, Poland.; Knippenberg, S (corresponding author), Palacky Univ Olomouc, Reg Ctr Adv Technol & Mat, Dept Phys Chem, Fac Sci, 17 Listopadu 12, Olomouc 77146, Czech Republic.; Knippenberg, S (corresponding author), KTH Royal Inst Technol, Dept Theoret Chem & Biol, Sch Engn Sci Chem Biotechnol & Hlth, SE-10691 Stockholm, Sweden.; Knippenberg, S (corresponding author), Hasselt Univ, Theory Lab, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | s.osella@cent.uw.edu.pl; marketa.paloncyova@gmail.com; msahi@kth.se; | - |
dc.description.notes | stefan.knippenberg@upol.cz | - |
dc.description.other | Knippenberg, S (corresponding author), Hasselt Univ, Theory Lab, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. s.osella@cent.uw.edu.pl; marketa.paloncyova@gmail.com; msahi@kth.se; stefan.knippenberg@upol.cz | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 4264 | - |
dc.identifier.doi | 10.3390/molecules25184264 | - |
dc.identifier.isi | WOS:000581844900001 | - |
dc.contributor.orcid | Paloncyova, Marketa/0000-0002-6811-7761; Osella, | - |
dc.contributor.orcid | Silvio/0000-0001-8541-1914; , Stefan/0000-0002-4527-2566 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Osella, Silvio] Univ Warsaw, Chem & Biol Syst Simulat Lab, Ctr New Technol, Banacha 2c, PL-02097 Warsaw, Poland. | - |
local.description.affiliation | [Paloncyova, Marketa; Knippenberg, Stefan] Palacky Univ Olomouc, Reg Ctr Adv Technol & Mat, Dept Phys Chem, Fac Sci, 17 Listopadu 12, Olomouc 77146, Czech Republic. | - |
local.description.affiliation | [Paloncyova, Marketa; Sahi, Maryam; Knippenberg, Stefan] KTH Royal Inst Technol, Dept Theoret Chem & Biol, Sch Engn Sci Chem Biotechnol & Hlth, SE-10691 Stockholm, Sweden. | - |
local.description.affiliation | [Knippenberg, Stefan] Hasselt Univ, Theory Lab, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Osella, Silvio; Paloncyova, Marketa; Sahi, Maryam & KNIPPENBERG, Stefan (2020) Influence of Membrane Phase on the Optical Properties of DPH. In: MOLECULES, 25 (18) (Art N° 4264). | - |
item.accessRights | Open Access | - |
item.contributor | Osella, Silvio | - |
item.contributor | Paloncyova, Marketa | - |
item.contributor | Sahi, Maryam | - |
item.contributor | KNIPPENBERG, Stefan | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
crisitem.journal.eissn | 1420-3049 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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molecules-25-04264-v2.pdf | Published version | 4.58 MB | Adobe PDF | View/Open |
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