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Title: | COVID-19 in multiple sclerosis and neuromyelitis optica spectrum disorder patients in Latin America COVID-19 in MS and NMOSD patients in LATAM | Authors: | Alonso, Ricardo Silva, Berenice Garcea, Orlando Correa Diaz, Patricio E. dos Passos, Giordani Rodrigues Ramirez Navarro, Deyanira A. Garcia Valle, Luis A. Rodriguez Salinas, Luis C. Negrotto, Laura Luetic, Geraldine Tkachuk, Veronica A. Miguez, Jimena Diaz de Bedoya, Fernando Hamuy Goiry, Lorna Galleguillos Ramirez Sanchez, Nicia E. Burgos, Marcos Steinberg, Judith Balbuena, Maria E. Monterrey Alvarez, Priscilla Lopez, Pablo A. Ysrraelit, Maria C. Leon, Rosalba A. Cohen, Aron Benzadon Gracia, Fernando Molina, Omaira Casas, Magdalena Deri, Norma H. Pappolla, Agustin Patrucco, Liliana Cristiano, Edgardo Tavolini, Dario Nadur, Debora Granda, Ana M. Toral Weiser, Roberto Cassara, Fatima Pagani Sinay, Vladimiro Carcamo Rodriguez, Claudia Lazaro, Luciana G. Menichini, Maria L. Piedrabuena, Raul Orozco Escobar, Geraldine Carra, Adriana Chertcoff, Anibal Santos Pujols, Biany Vrech, Carlos Tarulla, Adriana Carvajal, Rene Mainella, Carolina Becker, Jefferson PEETERS, Liesbet Walton, Clare Alonso Serena, Marina Nunez, Sebastian Rojas, Juan, I |
Issue Date: | 2021 | Publisher: | ELSEVIER SCI LTD | Source: | Multiple sclerosis and related disorders (Print), 51 (Art N° 102886) | Abstract: | Background: There is no data regarding COVID-19 in Multiple Sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) patients in Latin America. Objective: The objective of this study was to describe the clinical characteristics and outcomes of patients included in RELACOEM, a LATAM registry of MS and NMOSD patients infected with COVID-19. Methods: RELACOEM is a longitudinal, strictly observational registry of MS and NMOSD patients who suffer COVID-19 and Dengue in LATAM. Inclusion criteria to the registry were either: (1) a biologically confirmed COVID-19 diagnosis based on a positive result of a COVID-19 polymerase chain reaction (PCR) test on a naso-pharyngeal swab; or (2) COVID-19-typical symptoms (triad of cough, fever, and asthenia) in an epidemic zone of COVID-19. Descriptive statistics were performed on demographic and clinical variables. The cohort was later stratified for MS and NMOSD and univariate and multivariate logistic regression analysis was performed to identify variables associated with hospitalizations/intensive critical units (ICU) admission. Results: 145 patients were included in the registry from 15 countries and 51 treating physicians. A total of 129 (89%) were MS patients and 16 (11%) NMOSD. 81.4% patients had confirmed COVID-19 and 18.6% were suspected cases. 23 (15.8%) patients were hospitalized, 9 (6.2%) required ICU and 5 (3.4 %) died due to COVID-19. In MS patients, greater age (OR 1.17, 95% CI 1.05 - 1.25) and disease duration (OR 1.39, 95%CI 1.14-1.69) were associated with hospitalization/ICU. In NMOSD patients, a greater age (54.3 vs. 36 years, p=<0.001), increased EDSS (5.5 vs 2.9, p=0.0012) and disease duration (18.5 vs. 10.3 years, p=0.001) were significantly associated with hospitalization/ICU. Conclusion: we found that in MS patients, age and disease duration was associated with hospitalization and ICU admission requirement, while age, disease duration and EDSS was associated in NMOSD. | Notes: | Alonso, R (corresponding author), Univ Buenos Aires, Fac Med, Hosp Ramos Mejia, Ctr Univ Esclemsis Multiple CUEM, Urquiza 609,C1221 ADC, Caba, Argentina. | Keywords: | multiple sclerosis;NMOSD;COVID-19;registries;Latin America | Document URI: | http://hdl.handle.net/1942/35376 | ISSN: | 2211-0348 | e-ISSN: | 2211-0356 | DOI: | 10.1016/j.msard.2021.102886 | ISI #: | WOS:000689354300013 | Rights: | 2021 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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