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Title: | Lost in Space? Unmasking the T Cell Reaction to Simulated Space Stressors | Authors: | Miranda, Silvana Vermeesen, Randy Radstake, Wilhelmina E. Parisi, Alessio IVANOVA, Anna Baatout, Sarah Tabury, Kevin Baselet, Bjorn |
Issue Date: | 2023 | Publisher: | MDPI | Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (23) (Art N° 16943) | Abstract: | The space environment will expose astronauts to stressors like ionizing radiation, altered gravity fields and elevated cortisol levels, which pose a health risk. Understanding how the interplay between these stressors changes T cells' response is important to better characterize space-related immune dysfunction. We have exposed stimulated Jurkat cells to simulated space stressors (1 Gy, carbon ions/1 Gy photons, 1 mu M hydrocortisone (HC), Mars, moon, and microgravity) in a single or combined manner. Pro-inflammatory cytokine IL-2 was measured in the supernatant of Jurkat cells and at the mRNA level. Results show that alone, HC, Mars gravity and microgravity significantly decrease IL-2 presence in the supernatant. 1 Gy carbon ion irradiation showed a smaller impact on IL-2 levels than photon irradiation. Combining exposure to different simulated space stressors seems to have less immunosuppressive effects. Gene expression was less impacted at the time-point collected. These findings showcase a complex T cell response to different conditions and suggest the importance of elevated cortisol levels in the context of space flight, also highlighting the need to use simulated partial gravity technologies to better understand the immune system's response to the space environment. | Notes: | Baselet, B (corresponding author), Belgian Nucl Res Ctr SCK CEN, Radiobiol Unit, B-2400 Mol, Belgium. sfdsmira@sckcen.be; bbaselet@sckcen.be |
Keywords: | stress immunity;space radiobiology;altered gravity | Document URI: | http://hdl.handle.net/1942/42260 | ISSN: | 1661-6596 | e-ISSN: | 1422-0067 | DOI: | 10.3390/ijms242316943 | ISI #: | 001116631400001 | Rights: | 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Lost in Space_ Unmasking the T Cell Reaction to Simulated Space Stressors.pdf | Published version | 2.58 MB | Adobe PDF | View/Open |
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