Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9806
Title: Diamond nano-wires, a new approach towards next generation electrochemical gene sensor platforms
Authors: Nebel, C. E.
Yang, N.
Uetsuka, H.
Osawa, E.
Tokuda, N.
WILLIAMS, Oliver 
Issue Date: 2009
Publisher: ELSEVIER SCIENCE SA
Source: DIAMOND AND RELATED MATERIALS, 18(5-8). p. 910-917
Abstract: A novel bio-sensing platform is introduced by combination of a) geometrically controlled DNA bonding using vertically aligned diamond nano-wires and b) the superior electrochemical sensing properties of diamond as transducer material. Ultra-hard vertically aligned diamond nano-wires are electrochemically modified to bond phenyl linker-molecules to their tips which provide mesospacing for DNA molecules on the transducer. The nano-wires are generated by reactive ion etching of metallically boron doped atomically smooth single crystalline CVD diamond. Surface properties are characterized by atomic force, scanning electron and scanning tunneling microcopy. Electro- and bio-chemical sensor properties are investigated using cyclic and differential pulse voltammetry as well as impedance spectroscopy with Fe(CN)(6)(3-/4-) as redox mediators which reveal sensitivities of 2 pM on 3 mm 2 sensor areas and superior DNA bonding stability over 30 hybridization/denaturation cycles. The fabrication of "all diamond" ultra-micro-electrode (UME) arrays and multi-gene sensors are discussed taking into account the unique properties of diamond. (C) 2008 Elsevier B.V. All rights reserved.
Notes: [Nebel, C. E.] Fraunhofer Inst Appl Solid State Phys, D-79108 Freiburg, Germany. [Yang, N.; Uetsuka, H.] AIST, Diamond Res Ctr, Tsukuba, Ibaraki 3058568, Japan. [Osawa, E.] NanoCarbon Res Inst, Chiba 2770882, Japan. [Tokuda, N.] AIST, Nanotechnol Res Inst, Tsukuba, Ibaraki 3058568, Japan. [Williams, O.] Limburgs Univ Ctr, Inst Mat Inderzoek, B-3590 Diepenbeek, Belgium.
Keywords: Diamond; Gene-sensor; DNA; Ultra-micro-electrode array; Vertically aligned diamond nanowires
Document URI: http://hdl.handle.net/1942/9806
ISSN: 0925-9635
e-ISSN: 1879-0062
DOI: 10.1016/j.diamond.2008.11.024
ISI #: 000267737000049
Category: A1
Type: Journal Contribution
Validations: ecoom 2010
Appears in Collections:Research publications

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