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|Title:||Diamond nano-wires, a new approach towards next generation electrochemical gene sensor platforms||Authors:||Nebel, C. E.
|Issue Date:||2009||Publisher:||ELSEVIER SCIENCE SA||Source:||DIAMOND AND RELATED MATERIALS, 18(5-8). p. 910-917||Abstract:||A novel bio-sensing platform is introduced by combination of a) geometrically controlled DNA bonding using vertically aligned diamond nano-wires and b) the superior electrochemical sensing properties of diamond as transducer material. Ultra-hard vertically aligned diamond nano-wires are electrochemically modified to bond phenyl linker-molecules to their tips which provide mesospacing for DNA molecules on the transducer. The nano-wires are generated by reactive ion etching of metallically boron doped atomically smooth single crystalline CVD diamond. Surface properties are characterized by atomic force, scanning electron and scanning tunneling microcopy. Electro- and bio-chemical sensor properties are investigated using cyclic and differential pulse voltammetry as well as impedance spectroscopy with Fe(CN)(6)(3-/4-) as redox mediators which reveal sensitivities of 2 pM on 3 mm 2 sensor areas and superior DNA bonding stability over 30 hybridization/denaturation cycles. The fabrication of "all diamond" ultra-micro-electrode (UME) arrays and multi-gene sensors are discussed taking into account the unique properties of diamond. (C) 2008 Elsevier B.V. All rights reserved.||Notes:||[Nebel, C. E.] Fraunhofer Inst Appl Solid State Phys, D-79108 Freiburg, Germany. [Yang, N.; Uetsuka, H.] AIST, Diamond Res Ctr, Tsukuba, Ibaraki 3058568, Japan. [Osawa, E.] NanoCarbon Res Inst, Chiba 2770882, Japan. [Tokuda, N.] AIST, Nanotechnol Res Inst, Tsukuba, Ibaraki 3058568, Japan. [Williams, O.] Limburgs Univ Ctr, Inst Mat Inderzoek, B-3590 Diepenbeek, Belgium.||Keywords:||Diamond; Gene-sensor; DNA; Ultra-micro-electrode array; Vertically aligned diamond nanowires||Document URI:||http://hdl.handle.net/1942/9806||ISSN:||0925-9635||e-ISSN:||1879-0062||DOI:||10.1016/j.diamond.2008.11.024||ISI #:||000267737000049||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2010|
|Appears in Collections:||Research publications|
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