Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/14162
Title: | Correcting for cross-over bias in randomized controlled clinical trials | Authors: | Natukunda, Agnes | Advisors: | SHKEDY, Ziv VAN SANDEN, Suzy |
Issue Date: | 2012 | Publisher: | tUL Diepenbeek | Abstract: | Ideally, therapeutic interventions are evaluated through randomized clinical trials. These trials are commonly analysed with an intent-to-treat (ITT) approach, whereby patients are analyzed in their assigned treatment group regardless of actual treatment received. If an interim analysis of such trials demonstrates compelling evidence of a difference in benefit, ethical considerations often dictate that the trial be unblinded and participants be provided access to the more efficacious agent. Because interim analysis may not address longer-term outcomes of interest, important clinical questions such as overall survival benefit'the ultimate test of efficacy to many'may remain unanswered. The ensuing crossover disturbs randomization and may lead to biased longer-term analysis, compromising the utility of clinical data. In this thesis, I discuss the biases associated with ITT analysis and, alternatively, censoring of follow-up data after selective crossover. Moreover, discussed also is how | Notes: | Master of Statistics-Biostatistics | Document URI: | http://hdl.handle.net/1942/14162 | Category: | T2 | Type: | Theses and Dissertations |
Appears in Collections: | Master theses |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
10300072011009.pdf | 1.81 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.