Impact of high-intensity interval training on the glucose metabolism in MS

Abstract

Objective: The aim of this study was to investigate the effect of high-intensity interval training (HIIT) on the glucose metabolism of MS patients. Methods: Baseline differences in body composition and glucose metabolism between MS patients (MS) (n=29) and healthy controls (HC) (n=26) were determined by OGTT and DEXA-scan. Subsequently, the MS group was separated into an intervention group (EX) (n=16) which completed a 12 week HIIT protocol, and a sedentary control group (SED) (n=13). Glucose metabolism and body composition were investigated in both groups at baseline and after twelve weeks. Results: Baseline analysis showed significantly increased fasting serum insulin concentrations (p=0.0109) of the MS group compared to the HC group. Surprisingly, glucose total area under the curve (tAUC) (p=0.0244) of SED was significantly decreased after twelve weeks. Within-group analysis of the EX group showed a significant decrease in fasting serum insulin (p=0.0495) and HOMA-IR (p=0.0245) concentrations.