Effects of inhibition of adipose tissue lipolysis during exercise on glycaemic control and exercise performance in patients with type 2 diabetes mellitus

Abstract

Background: In type 2 diabetes mellitus (T2DM), hypertriglyceridemia is associated with insulin resistance. A single bout of endurance exercise with inhibition of adipose tissue lipolysis (using acipimox) results in a more pronounced short-term improvement in glycaemic control, compared to exercise alone. However, its effect on postprandial periods remains unknown. Furthermore, the effect of acipimox on exercise performance has not been investigated previously. Objectives: Part 1: To examine parameters of glycaemic control after a single bout of endurance exercise using acipimox concomitantly, with emphasis on the postprandial phase. Part 2: To assess the effect of acipimox on exercise performance during cardiopulmonary exercise testing (CPET), to determine whether heartrate-based (or other known methods for intensity determination) endurance exercise is suitable when using acipimox concomitantly. Conclusion: Part 1: endurance exercise with acipimox intake results in lower post-exercise and postprandial plasma glucose and insulin levels and lower postprandial glucose excursion. Part 2: %VO2peak, %HRpeak and %Wpeak are feasible methods for endurance exercise intensity determination in T2DM patients.