Cardiac dysfunction in adolescents with type 1 diabetes: contribution of daily-life glucoregulation and impact on cardiorespiratory exercise capacity

Abstract

Objectives: To examine exercise tolerance and cardiac function in adolescents with T1DM vs. healthy controls, and their interrelations. In addition, we aimed to study the relation between glycemic control and cardiac function/structure or exercise tolerance. Participants: Fourteen participants between 12 and 18 years old with the diagnosis of T1DM and fourteen healthy controls were included. Conclusion: Exercise tolerance and cardiac function were preserved in T1DM, but a higher mean [BG] seems to be correlated with a lower VO2peak. A greater total time in hypoglycemic state was correlated with a higher VO2/Wpeak, indicating that glycemic control is related to exercise tolerance.