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Title: Equivalence testing in protein binding
Authors: SHI, Xiaofeng
Advisors: MARINGWA, J.
Issue Date: 2007
Abstract: Various routes are used to administer drugs but in most cases drugs reach their site of action via the systemic circulation. After a drug is absorbed into the bloodstream, it rapidly circulates through the body. A drug in blood exists only in two forms as mentioned above, which are bound and unbound. The unbound part generally exhibits pharmacologic effects. The main objective of this study is to find out whether males and females have equivalent values for protein binding. And the second objective is to decide if one of two measurements could be dropped. By using equivalence test, the results suggest that males and females are not equivalent in each species. Besides, by using simulation one of these two measurements can be dropped.
Notes: Master in Applied Statistics
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Category: T2
Type: Theses and Dissertations
Appears in Collections:Applied Statistics: Master theses

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