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http://hdl.handle.net/1942/40303
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DC Field | Value | Language |
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dc.date.accessioned | 2023-06-05T11:40:59Z | - |
dc.date.available | 2023-06-05T11:40:59Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2023-06-05T07:58:39Z | - |
dc.identifier.citation | PLOS Pathogens; Figshare. 10.1371/journal.ppat.1010848.s001 10.1371/journal.ppat.1010848.s002 10.1371/journal.ppat.1010848.s003 10.1371/journal.ppat.1010848.s004 10.1371/journal.ppat.1010848.s005 10.1371/journal.ppat.1010848.s006 | - |
dc.identifier.uri | http://hdl.handle.net/1942/40303 | - |
dc.description.abstract | Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequences for the pathogen remain poorly understood. Here, we addressed this question in vitro and present the first integrated analysis of the genome, transcriptome, proteome, and metabolome of highly aneuploid Leishmania donovani strains. Our analyses unambiguously establish that aneuploidy in Leishmania proportionally impacts the average transcript- and protein abundance levels of affected chromosomes, ultimately correlating with the degree of metabolic differences between closely related aneuploid strains. This proportionality was present in both proliferative and non-proliferative in vitro promastigotes. However, as in other Eukaryotes, we observed attenuation of dosage effects for protein complex subunits and in addition, non-cytoplasmic proteins. Differentially expressed transcripts and proteins between aneuploid Leishmania strains also originated from non-aneuploid chromosomes. At protein level, these were enriched for proteins involved in protein metabolism, such as chaperones and chaperonins, peptidases, and heat-shock proteins. In conclusion, our results further support the view that aneuploidy in Leishmania can be adaptive. Additionally, we believe that the high karyotype diversity in vitro and absence of classical transcriptional regulation make Leishmania an attractive model to study processes of protein homeostasis in the context of aneuploidy and beyond. | - |
dc.description.sponsorship | Fonds Wetenschappelijk Onderzoek (FWO): post-doc fellowship to Bart Cuypers (11O1614N) | - |
dc.description.sponsorship | Interuniversity Attraction Poles Program of Belgian Science Policy (P7/41) to Jean-Claude Dujardin | - |
dc.description.sponsorship | InBev Baillet-Latour foundation to Jean-Claude Dujardin | - |
dc.description.sponsorship | Department of Economy, Science and Innovation in Flanders (ITM-SOFIB, SINGLE to Jean-Claude Dujardin) | - |
dc.language.iso | en | - |
dc.publisher | PLOS Pathogens; Figshare | - |
dc.subject.classification | Parasitology | - |
dc.subject.other | Aneuploidy | - |
dc.subject.other | Protein metabolism | - |
dc.subject.other | Leishmania | - |
dc.subject.other | Leishmania donovani | - |
dc.subject.other | Genomics | - |
dc.subject.other | Transcriptome analysis | - |
dc.subject.other | Proteomes | - |
dc.subject.other | Protein abundance | - |
dc.title | Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania | - |
dc.type | Dataset | - |
local.bibliographicCitation.jcat | DS | - |
dc.rights.license | Creative Commons Attribution 4.0 International (CC-BY-4.0) | - |
dc.identifier.doi | 10.1371/journal.ppat.1010848.s001 | - |
dc.identifier.doi | 10.1371/journal.ppat.1010848.s002 | - |
dc.identifier.doi | 10.1371/journal.ppat.1010848.s003 | - |
dc.identifier.doi | 10.1371/journal.ppat.1010848.s004 | - |
dc.identifier.doi | 10.1371/journal.ppat.1010848.s005 | - |
dc.identifier.doi | 10.1371/journal.ppat.1010848.s006 | - |
dc.description.other | The raw genomic and transcriptomic data in this study is available at the NCBI Sequence Read Archive (SRA) under the accession code: PRJNA762444. Raw proteomic data has been submitted to the PRIDE database under reference PXD028521. Raw metabolomic data was submitted to the MetaboLights database under accession code MTBLS1612 [67]. [67] Haug K, Cochrane K, Nainala VC, Williams M, Chang J, Jayaseelan KV, et al. MetaboLights: a resource evolving in response to the needs of its scientific community. Nucleic acids research. 2020;48(D1):D440–d4. pmid:31691833 | - |
local.provider.type | CrossRef | - |
local.uhasselt.international | yes | - |
local.contributor.datacreator | Cuypers, Bart | - |
local.contributor.datacreator | Meysman, Pieter | - |
local.contributor.datacreator | Erb, Ionas | - |
local.contributor.datacreator | Bittremieux, Wout | - |
local.contributor.datacreator | VALKENBORG, Dirk | - |
local.contributor.datacreator | Baggerman, Geert | - |
local.contributor.datacreator | Mertens, Inge | - |
local.contributor.datacreator | Sundar, Shyam | - |
local.contributor.datacreator | Khanal, Basudha | - |
local.contributor.datacreator | Notredame, Cedric | - |
local.contributor.datacreator | Dujardin, Jean-Claude | - |
local.contributor.datacreator | Domagalska, Malgorzata A. | - |
local.contributor.datacreator | Laukens, Kris | - |
local.contributor.datacurator | Cuypers, Bart | - |
local.contributor.rightsholder | Cuypers, Bart | - |
local.format.mimetype | .XLSX | - |
local.format.mimetype | .DOCX | - |
local.format.mimetype | Extensible Markup Language (XML) | - |
local.format.mimetype | .TXT | - |
local.format.mimetype | .GZ | - |
local.contributororcid.datacreator | 0000-0002-7198-1470 | - |
local.contributororcid.datacreator | 0000-0001-5903-633X | - |
local.contributororcid.datacreator | 0000-0002-2331-9714 | - |
local.contributororcid.datacreator | 0000-0002-3105-1359 | - |
local.contributororcid.datacreator | 0000-0002-0661-931X | - |
local.contributororcid.datacreator | 0000-0002-4888-3485 | - |
local.contributororcid.datacreator | 0000-0001-9988-582X | - |
local.contributororcid.datacreator | 0000-0003-4340-6062 | - |
local.contributororcid.datacreator | 0000-0003-1461-0988 | - |
local.contributororcid.datacreator | 0000-0002-9217-5240 | - |
local.contributororcid.datacreator | 0000-0003-0839-0325 | - |
local.contributororcid.datacreator | 0000-0002-8217-2564 | - |
local.contributororcid.datacurator | 0000-0002-7198-1470 | - |
local.contributororcid.rightsholder | 0000-0002-7198-1470 | - |
local.publication.doi | 10.1371/journal.ppat.1010848 | - |
local.contributingorg.datacreator | Institute of Tropical Medicine, Antwerp, Belgium | - |
local.contributingorg.datacreator | University of Antwerp, Antwerp, Belgium | - |
local.contributingorg.datacurator | Institute of Tropical Medicine, Antwerp, Belgium | - |
local.contributingorg.datacurator | University of Antwerp, Antwerp, Belgium | - |
local.contributingorg.rightsholder | Institute of Tropical Medicine, Antwerp, Belgium | - |
local.contributingorg.rightsholder | University of Antwerp, Antwerp, Belgium | - |
dc.rights.access | Open Access | - |
item.accessRights | Closed Access | - |
item.contributor | Cuypers, Bart | - |
item.contributor | Meysman, Pieter | - |
item.contributor | Erb, Ionas | - |
item.contributor | Bittremieux, Wout | - |
item.contributor | VALKENBORG, Dirk | - |
item.contributor | Baggerman, Geert | - |
item.contributor | Mertens, Inge | - |
item.contributor | Sundar, Shyam | - |
item.contributor | Khanal, Basudha | - |
item.contributor | Notredame, Cedric | - |
item.contributor | Dujardin, Jean-Claude | - |
item.contributor | Domagalska, Malgorzata A. | - |
item.contributor | Laukens, Kris | - |
item.fullcitation | Cuypers, Bart; Meysman, Pieter; Erb, Ionas; Bittremieux, Wout; VALKENBORG, Dirk; Baggerman, Geert; Mertens, Inge; Sundar, Shyam; Khanal, Basudha; Notredame, Cedric; Dujardin, Jean-Claude; Domagalska, Malgorzata A. & Laukens, Kris (2022) Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania. PLOS Pathogens; Figshare. 10.1371/journal.ppat.1010848.s001 10.1371/journal.ppat.1010848.s002 10.1371/journal.ppat.1010848.s003 10.1371/journal.ppat.1010848.s004 10.1371/journal.ppat.1010848.s005 10.1371/journal.ppat.1010848.s006. | - |
item.fulltext | No Fulltext | - |
crisitem.discipline.code | 03012006 | - |
crisitem.discipline.name | Parasitology | - |
crisitem.discipline.path | Medical and health sciences > Basic sciences > Microbiology > Parasitology | - |
crisitem.discipline.pathandcode | Medical and health sciences > Basic sciences > Microbiology > Parasitology (03012006) | - |
crisitem.license.code | CC-BY-4.0 | - |
crisitem.license.name | Creative Commons Attribution 4.0 International (CC-BY-4.0) | - |
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