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Title: Novel maternal autoantibodies in autism spectrum disorder: Implications for screening and diagnosis
Authors: MAZON CABRERA, Rut 
BRONE, Bert 
SOMERS, Veerle 
Issue Date: 2023
Source: Frontiers in neuroscience (Print), 17 (Art N° 1067833)
Abstract: IntroductionAutism spectrum disorder (ASD) is a complex neurodevelopmental disorder for which early recognition is a major challenge. Autoantibodies against fetal brain antigens have been found in the blood of mothers of children with ASD (m-ASD) and can be transferred to the fetus where they can impact neurodevelopment by binding to fetal brain proteins. This study aims to identify novel maternal autoantibodies reactive against human fetal brain antigens, and explore their use as biomarkers for ASD screening and diagnosis. MethodsA custom-made human fetal brain cDNA phage display library was constructed, and screened for antibody reactivity in m-ASD samples from the Simons Simplex Collection (SSC) of the Simons Foundation Autism Research Initiative (SFARI). Antibody reactivity against 6 identified antigens was determined in plasma samples of 238 m-ASD and 90 mothers with typically developing children (m-TD). ResultsWe identified antibodies to 6 novel University Hasselt (UH)-ASD antigens, including three novel m-ASD autoantigens, i.e., ribosomal protein L23 (RPL23), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and calmodulin-regulated spectrin-associated protein 3 (CAMSAP3). Antibody reactivity against a panel of four of these targets was found in 16% of m-ASD samples, compared to 4% in m-TD samples (p = 0.0049). DiscussionMaternal antibodies against 4 UH-ASD antigens could therefore provide a novel tool to support the diagnosis of ASD in a subset of individuals.
Notes: Somers, V (corresponding author), UHasselt Transnatl Univ Limburg, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium.
Keywords: autoantibodies;autism spectrum disorder;risk factor;pregnancy;biomarker
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ISSN: 1662-4548
DOI: 10.3389/fnins.2023.1067833
ISI #: 000937269500001
Rights: 2023 Mazón-Cabrera, Liesenborgs, Brône, Vandormael and Somers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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