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http://hdl.handle.net/1942/10015
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DC Field | Value | Language |
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dc.contributor.author | Baecker, M. | - |
dc.contributor.author | Beging, S. | - |
dc.contributor.author | Biselli, M. | - |
dc.contributor.author | Poghossian, A. | - |
dc.contributor.author | Wang, J. | - |
dc.contributor.author | Zang, W. | - |
dc.contributor.author | WAGNER, Patrick | - |
dc.contributor.author | Schoening, M. J. | - |
dc.date.accessioned | 2009-11-20T16:07:08Z | - |
dc.date.available | 2009-11-20T16:07:08Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | ELECTROCHIMICA ACTA, 54(25). p. 6107-6112 | - |
dc.identifier.issn | 0013-4686 | - |
dc.identifier.uri | http://hdl.handle.net/1942/10015 | - |
dc.description.abstract | In this study. a concept for a silicon-based modular solid-state sensor system for inline multi-parameter monitoring of cell-culture fermentation processes is presented. The envisaged multi-parameter sensor system consists of two identical sensor modules and is intended for continuous quantification of up to five (bio-)chemical and physical parameters, namely, glucose and glutamine concentration, pH value, electrolyte conductivity and temperature by applying different transducer principles and/or different operation modes. Experimental results for the field-effect electrolyte-insulator-semiconductor (EIS) sterilisable pH sensor and electrolyte conductivity sensor based on interdigitated electrodes are presented. The ongoing autoclaving does not have any significant impact on the pH-sensitive properties of a Ta(2)O(5-)gate EIS sensor. Even after 30 autoclaving cycles, the pH sensors show a clear pH response and nearly linear calibration curve with a slope of 57 +/- 1 mV/pH. Additional scanning electron microscopy and ellipsometric investigations do not show any visible surface degradation or changes in the thickness of the pH-sensitive Ta2O5 layer. The preliminary results demonstrate the suitability of the developed EIS, sensor for an inline pH measurement during a fermentation process. in addition, interdigitated electrodes of different geometries serving as electrolyte conductivity sensor have been tested for measurements in relatively high ionic-strength solutions. (C) 2009 Elsevier Ltd. All rights reserved. | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject.other | Fermentation process; pH; Field-effect; Electrolyte conductivity; Multi-parameter detection | - |
dc.title | Concept for a solid-state multi-parameter sensor system for cell-culture monitoring | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 6112 | - |
dc.identifier.issue | 25 | - |
dc.identifier.spage | 6107 | - |
dc.identifier.volume | 54 | - |
local.format.pages | 6 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Baecker, M.; Beging, S.; Biselli, M.; Poghossian, A.; Wang, J.; Schoening, M. J.] Aachen Univ Appl Sci, INB, Aachen, Germany. [Baecker, M.; Beging, S.; Poghossian, A.; Wang, J.; Schoening, M. J.] Res Ctr Julich GmbH, Inst Bio & Nanosyst IBN 2, Julich, Germany. [Zang, W.] HiTec Zang GmbH, Herzogenrath, Germany. [Wagner, P.] Hasselt Univ, Inst Mat Res, Diepenbeek, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1016/j.electacta.2009.02.091 | - |
dc.identifier.isi | 000270347200026 | - |
item.fullcitation | Baecker, M.; Beging, S.; Biselli, M.; Poghossian, A.; Wang, J.; Zang, W.; WAGNER, Patrick & Schoening, M. J. (2009) Concept for a solid-state multi-parameter sensor system for cell-culture monitoring. In: ELECTROCHIMICA ACTA, 54(25). p. 6107-6112. | - |
item.accessRights | Closed Access | - |
item.fulltext | No Fulltext | - |
item.contributor | Baecker, M. | - |
item.contributor | Beging, S. | - |
item.contributor | Biselli, M. | - |
item.contributor | Poghossian, A. | - |
item.contributor | Wang, J. | - |
item.contributor | Zang, W. | - |
item.contributor | WAGNER, Patrick | - |
item.contributor | Schoening, M. J. | - |
item.validation | ecoom 2010 | - |
crisitem.journal.issn | 0013-4686 | - |
crisitem.journal.eissn | 1873-3859 | - |
Appears in Collections: | Research publications |
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