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http://hdl.handle.net/1942/10274
Title: | Potential role for ligand-gated ion channels after seizure-induced neurogenesis | Authors: | SWIJSEN, Ann HOOGLAND, Govert RIGO, Jean-Michel |
Issue Date: | 2009 | Publisher: | PORTLAND PRESS LTD | Source: | BIOCHEMICAL SOCIETY TRANSACTIONS, 37. p. 1419-1422 | Abstract: | Epileptic seizures result in an increased generation of new neurons in the dentate gyrus of the adult mammalian hippocampus. The role of these seizure-induced newborn neurons in the process of epileptogenesis remains largely unknown. Recent work, however, suggests an aberrant incorporation of newborn cells into the existing hippocampal network in such a way that they promote hippocampal hyperexcitability. in the present review, we discuss current knowledge about the possible role of seizure-induced newly generated neurons and the putative involvement of ligand-gated ion channels in the process of epileptogenesis. | Notes: | [Swijsen, Ann; Rigo, Jean-Michel] Hasselt Univ, BIOMED Res Inst, B-3590 Diepenbeek, Belgium. [Swijsen, Ann; Rigo, Jean-Michel] Transnatl Univ Limburg, B-3590 Diepenbeek, Belgium. [Hoogland, Govert] Univ Med Ctr Maastricht, Dept Neurosurg, Maastricht, Netherlands. [Hoogland, Govert] Univ Med Ctr Maastricht, Sch Mental Hlth & Neurosci, Maastricht, Netherlands. jeanmichel.rigo@uhasselt.be | Keywords: | adult neurogenesis; hippocampus; hyperexcitability; ligand-gated ion channel; seizure; temporal lobe epilepsy;adult neurogenesis; hippocampus; hyperexcitability; ligand-gated ion channel; seizure; temporal lobe epilepsy | Document URI: | http://hdl.handle.net/1942/10274 | ISSN: | 0300-5127 | e-ISSN: | 1470-8752 | DOI: | 10.1042/BST0371419 | ISI #: | 000272646000052 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2010 |
Appears in Collections: | Research publications |
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