Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10426
Title: Analysis of antibody reactivity in paired cerebrospinal fluid and serum of a relapsing remitting multiple sclerosis patient
Authors: GOVARTS, Cindy 
SOMERS, Klaartje 
Hupperts, R.
STINISSEN, Piet 
SOMERS, Veerle 
Issue Date: 2009
Publisher: TAYLOR & FRANCIS LTD
Source: AUTOIMMUNITY, 42 (8). p. 699-704
Abstract: Increasing evidence indicates an involvement of B cells in multiple sclerosis (MS). However, little is known about antigenic targets recognized by antibodies present in blood and cerebrospinal fluid (CSF) of MS patients. This study was therefore aimed at identifying the antigen reactivity of antibodies present in CSF and compares the identified antibody profile with that of the serum of the same patient using cDNA phage display. Selection rounds on paired CSF and serum of this patient identified 13 antigenic targets of which 5 were enriched by serum antibodies and 2 were identified by CSF antibodies. Interestingly, the six remaining antigenic targets were shown to be recognized by both CSF and serum antibodies. These findings point towards both common as well as distinct antibody profiles in CSF and serum of MS patients.
Notes: [Somers, V.] Hasselt Univ, Biomed Res Inst, Sch Life Sci, Transnatl Univ Limburg, B-3590 Diepenbeek, Belgium. [Hupperts, R.] Maastricht Univ, Sch Mental Hlth & Neurosci, Med Ctr, Maastricht, Netherlands. [Hupperts, R.] Orbis Med Ctr, Dept Neurol, Sittard, Netherlands. veerle.somers@uhasselt.be
Keywords: Multiple sclerosis; cDNA phage display; antibodies; CSF; serum;Multiple sclerosis; cDNA phage display; antibodies; CSF; serum
Document URI: http://hdl.handle.net/1942/10426
ISSN: 0891-6934
e-ISSN: 1607-842X
DOI: 10.3109/08916930903176513
ISI #: 000273447700008
Category: A1
Type: Journal Contribution
Validations: ecoom 2011
Appears in Collections:Research publications

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