Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10459
Title: Measuring metacarpal cortical bone by digital x-ray radiogrammetry: a step forward?
Authors: GEUSENS, Piet 
Lems, Willem F.
Issue Date: 2009
Publisher: BIOMED CENTRAL LTD
Source: ARTHRITIS RESEARCH & THERAPY, 11 (5)
Abstract: Changes in metacarpal cortical bone mineral density (BMD) using digital x-ray radiogrammetry were studied in patients with early rheumatoid arthritis. After 1, 2, and 5 years, large BMD losses were found: -1.7%, -2.8%, and -5.6%, respectively. Elevated erythrocyte sedimentation rate and anti-cyclic citrullinated peptide levels were independent predictors of bone loss, indicating that the largest amount of bone loss was found in patients with severe inflammation and high production of auto-antibodies, who are known to be at the highest risk of developing radiological bone damage. Studies are needed about the spatial and time relationship between erosions and juxta-articular and metacarpal bone loss.
Notes: [Geusens, Piet P.] Maastricht Univ, Med Ctr, Dept Internal Med, Subdiv Rheumatol, NL-6202 AZ Maastricht, Netherlands. [Geusens, Piet P.] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Lems, Willem F.] Vrije Univ Amsterdam, Med Ctr, Dept Rheumatol, NL-1007 MB Amsterdam, Netherlands. piet.geusens@scarlet.be
Document URI: http://hdl.handle.net/1942/10459
ISSN: 1478-6362
DOI: 10.1186/ar2788
ISI #: 000273338400004
Category: M
Type: Journal Contribution
Appears in Collections:Research publications

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