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http://hdl.handle.net/1942/10459
Title: | Measuring metacarpal cortical bone by digital x-ray radiogrammetry: a step forward? | Authors: | GEUSENS, Piet Lems, Willem F. |
Issue Date: | 2009 | Publisher: | BIOMED CENTRAL LTD | Source: | ARTHRITIS RESEARCH & THERAPY, 11 (5) | Abstract: | Changes in metacarpal cortical bone mineral density (BMD) using digital x-ray radiogrammetry were studied in patients with early rheumatoid arthritis. After 1, 2, and 5 years, large BMD losses were found: -1.7%, -2.8%, and -5.6%, respectively. Elevated erythrocyte sedimentation rate and anti-cyclic citrullinated peptide levels were independent predictors of bone loss, indicating that the largest amount of bone loss was found in patients with severe inflammation and high production of auto-antibodies, who are known to be at the highest risk of developing radiological bone damage. Studies are needed about the spatial and time relationship between erosions and juxta-articular and metacarpal bone loss. | Notes: | [Geusens, Piet P.] Maastricht Univ, Med Ctr, Dept Internal Med, Subdiv Rheumatol, NL-6202 AZ Maastricht, Netherlands. [Geusens, Piet P.] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Lems, Willem F.] Vrije Univ Amsterdam, Med Ctr, Dept Rheumatol, NL-1007 MB Amsterdam, Netherlands. piet.geusens@scarlet.be | Document URI: | http://hdl.handle.net/1942/10459 | ISSN: | 1478-6354 | e-ISSN: | 1478-6362 | DOI: | 10.1186/ar2788 | ISI #: | 000273338400004 | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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ar2788.pdf | Published version | 44.03 kB | Adobe PDF | View/Open |
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