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http://hdl.handle.net/1942/10614
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DC Field | Value | Language |
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dc.contributor.author | Casteels, Kristina | - |
dc.contributor.author | FIEUWS, Steffen | - |
dc.contributor.author | van Helvoirt, Maria | - |
dc.contributor.author | Verpoorten, Carla | - |
dc.contributor.author | Goemans, Nathalie | - |
dc.contributor.author | Coudyzer, Walter | - |
dc.contributor.author | Loeckx, Dirk | - |
dc.contributor.author | de Zegher, Francis | - |
dc.date.accessioned | 2010-02-23T15:54:49Z | - |
dc.date.available | 2010-02-23T15:54:49Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | PEDIATRIC DIABETES, 11 (1). p. 61-69 | - |
dc.identifier.issn | 1399-543X | - |
dc.identifier.uri | http://hdl.handle.net/1942/10614 | - |
dc.description.abstract | The aim of this randomized, placebo-controlled study was to explore the effect of metformin in children with a neurogenic or myogenic motor deficit, who are therefore prone to develop overweight, adiposity, and insulin resistance. Study participants (n = 42) had a mean age of 15.5 yr, a short stature (height -2.4 SD), a relatively high BMI (+1.7 SD), and a high body fat fraction (41.9% or +2.8 SD). Abdominal CT confirmed the high fat mass and disclosed a high fraction of visceral fat. As expected, insulin resistance was increased. As compared to placebo, metformin intake for 6 months exerted an insulin sensitizing effect and lowered weight (mean difference of 2 kg within 6 months, p = 0.007) and BMI (p = 0.016). Weight loss appeared to be primarily due to loss of visceral fat (similar to 20% vs. placebo; p < 0.0001). Results were similar across diagnostic subgroups. In conclusion, metformin treatment for 6 months was associated with a rise in insulin sensitivity and with a reduction of visceral adiposity in children and adolescents with a primary muscle disorder or with a neural tube defect. These findings suggest that insulin resistance underpins, at least partly, the overweight and visceral adiposity of these patients, who are not necessarily obese. | - |
dc.description.sponsorship | The present work was supported by the Fund for Scientific Research (G.0326.06); KC and FdZ are Clinical Investigators, and DL is a Postdoctoral Fellow, each of the Fund for Scientific Research (Flanders, Belgium). | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | - |
dc.subject.other | body composition; insulin resistance; metformin; neural tube defect; neuromuscular disease | - |
dc.subject.other | body composition; insulin resistance; metformin; neural tube defect; neuromuscular disease | - |
dc.title | Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficit | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 69 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 61 | - |
dc.identifier.volume | 11 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Casteels, Kristina; van Helvoirt, Maria; Verpoorten, Carla; Goemans, Nathalie; de Zegher, Francis] UZ Leuven, Dept Pediat, B-3000 Leuven, Belgium. [Fieuws, Steffen] Katholieke Univ Leuven, I BioStat, Leuven, Belgium. [Fieuws, Steffen] Univ Hasselt, Leuven, Belgium. [Coudyzer, Walter] UZ Leuven, Dept Radiol, Leuven, Belgium. [Loeckx, Dirk] Katholieke Univ Leuven, Fac Engn, ESAT PSI, Leuven, Belgium. Kristina.casteels@uzleuven.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1111/j.1399-5448.2009.00512.x | - |
dc.identifier.isi | 000274188900011 | - |
item.fullcitation | Casteels, Kristina; FIEUWS, Steffen; van Helvoirt, Maria; Verpoorten, Carla; Goemans, Nathalie; Coudyzer, Walter; Loeckx, Dirk & de Zegher, Francis (2010) Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficit. In: PEDIATRIC DIABETES, 11 (1). p. 61-69. | - |
item.contributor | Casteels, Kristina | - |
item.contributor | FIEUWS, Steffen | - |
item.contributor | van Helvoirt, Maria | - |
item.contributor | Verpoorten, Carla | - |
item.contributor | Goemans, Nathalie | - |
item.contributor | Coudyzer, Walter | - |
item.contributor | Loeckx, Dirk | - |
item.contributor | de Zegher, Francis | - |
item.accessRights | Restricted Access | - |
item.validation | ecoom 2011 | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1399-543X | - |
crisitem.journal.eissn | 1399-5448 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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steffen.pdf Restricted Access | Published version | 1.04 MB | Adobe PDF | View/Open Request a copy |
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