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http://hdl.handle.net/1942/10702
Title: | Therapeutic vaccines for autoimmune Diseases | Authors: | PANNEMANS, Kim HELLINGS, Niels STINISSEN, Piet |
Issue Date: | 2010 | Publisher: | Elsevier | Source: | Drug Discovery Today: Therapeutic Strategies, 6(1), p. 39-44 | Abstract: | The immune system has developed several checkpoints to prevent the induction of autoimmune diseases like multiple sclerosis and rheumatoid arthritis. Autoreactive T cells are negatively selected in the thymus but can escape this selection procedure. Peripherally, they are further controlled by homeostatic mechanisms and regulatory T cells (Tregs). Genetic and exogenous factors as well as a disbalanced functioning of Tregs may all influence these checkpoints and contribute to the breakdown of tolerance against ‘self’. Re-establishment of tolerance can be achieved by different vaccination strategies, which are divided into three major groups based on the composition of the vaccine: DNA vaccination, peptide-based-vaccination and T cell vaccination. This review summarizes the mechanisms, clinical trials and pros and cons of these different vaccination strategies. | Document URI: | http://hdl.handle.net/1942/10702 | ISSN: | 1359-6446 | e-ISSN: | 1878-5832 | DOI: | 10.1016/j.ddstr.2009.11.001 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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