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http://hdl.handle.net/1942/10710
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DC Field | Value | Language |
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dc.contributor.author | BROUX, Bieke | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.contributor.author | VENKEN, Koen | - |
dc.contributor.author | RUMMENS, Jean-Luc | - |
dc.contributor.author | HENSEN, Karen | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.date.accessioned | 2010-03-13T09:56:04Z | - |
dc.date.available | 2010-03-13T09:56:04Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | GENES AND IMMUNITY, 11(4). p. 323-336 | - |
dc.identifier.issn | 1466-4879 | - |
dc.identifier.uri | http://hdl.handle.net/1942/10710 | - |
dc.description.abstract | The receptor for the homeostatic T cell cytokine interleukin-7 (IL-7Ralpha) has recently shown genetic association to multiple sclerosis (MS). To investigate the functional contribution of IL-7Ralpha polymorphisms to the pathogenesis of MS, we correlated the IL-7Ralpha haplotypes with different T cell parameters in a group of MS patients and healthy controls. We show that carriers of one of the four IL-7Ralpha haplotypes (Hap4) show a higher expression of IL-7Ralpha (CD127) on their CD4(+) T cells, compared with noncarriers (P=0.04). Moreover, Hap4 carriers possess higher frequencies of recent thymic emigrants (RTEs, CD31(+)) in both the regulatory T cell (Treg; P=0.007) and conventional T cell (Tconv) population (P=0.0001). This effect is most pronounced within the MS population (Treg, P=0.0077; Tconv, P=0.0007), whereas in healthy controls significance was only reached for Tconv (P=0.043; Treg, P=0.11). Because previous studies showed a decreased RTE-Treg frequency in MS patients compared to healthy subjects, we here conclude that this decrease is localized within the MS population of non-Hap4 carriers. In conclusion, our findings suggest that IL-7Ralpha polymorphisms can influence T cell development and homeostasis, and thereby contribute to the altered immune regulation associated with disease development in patients with MS.Genes and Immunity advance online publication, 14 January 2010; doi:10.1038/gene.2009.106. | - |
dc.language | ENG | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Haplotype 4 of the multiple sclerosis-associated interleukin-7 receptor alpha gene influences the frequency of recent thymic emigrants. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 336 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 323 | - |
dc.identifier.volume | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Biomedical Research Institute, Hasselt University and School of Life Sciences, transnationale Universiteit Limburg, Diepenbeek, Belgium. | - |
dc.relation.pmid | 20072142 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1038/gene.2009.106 | - |
dc.identifier.isi | 000278291000005 | - |
item.validation | ecoom 2011 | - |
item.accessRights | Open Access | - |
item.fullcitation | BROUX, Bieke; HELLINGS, Niels; VENKEN, Koen; RUMMENS, Jean-Luc; HENSEN, Karen; VAN WIJMEERSCH, Bart & STINISSEN, Piet (2010) Haplotype 4 of the multiple sclerosis-associated interleukin-7 receptor alpha gene influences the frequency of recent thymic emigrants.. In: GENES AND IMMUNITY, 11(4). p. 323-336. | - |
item.fulltext | With Fulltext | - |
item.contributor | BROUX, Bieke | - |
item.contributor | HELLINGS, Niels | - |
item.contributor | VENKEN, Koen | - |
item.contributor | RUMMENS, Jean-Luc | - |
item.contributor | HENSEN, Karen | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | STINISSEN, Piet | - |
crisitem.journal.issn | 1466-4879 | - |
crisitem.journal.eissn | 1476-5470 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Broux et al DocServer.pdf | Non Peer-reviewed author version | 565.73 kB | Adobe PDF | View/Open |
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