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http://hdl.handle.net/1942/11098
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DC Field | Value | Language |
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dc.contributor.author | Richart, Tom | - |
dc.contributor.author | Thijs, Lutgarde | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Yu, Jin | - |
dc.contributor.author | Kuznetsova, Tatiana | - |
dc.contributor.author | Balkestein, Elisabeth J. | - |
dc.contributor.author | Struijker-Boudier, Harry A. | - |
dc.contributor.author | Staessen, Jan A. | - |
dc.date.accessioned | 2010-08-09T12:06:52Z | - |
dc.date.available | NO_RESTRICTION | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | AMERICAN JOURNAL OF HYPERTENSION, 24(1). p. 102-109 | - |
dc.identifier.issn | 0895-7061 | - |
dc.identifier.uri | http://hdl.handle.net/1942/11098 | - |
dc.description.abstract | Backgound: Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure, and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D3 might be associated with the metabolic syndrome (MS) and arterial calcification. Methods: In a random population sample (n = 542; 50.5% women; mean age, 49.8 ± 13.1 years), we measured MS prevalence (International Diabetes Federation (IDF) and American Heart Association (AHA) criteria), PTH and 25-OH-D3, serum and 24-h urinary calcium, MS components, carotid intima-media thickness (CIMT), and calcium intake from dairy products. We assessed associations in multivariable-adjusted analyses, using linear and logistic regressions. Results: The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA criteria). MS prevalence, blood pressure, waist circumference, body mass index, fasting blood glucose, insulin and triglycerides, and CIMT increased (P = 0.042) across quartiles of the PTH/25-OH-D3 ratio, whereas serum and 24-h urinary calcium decreased (P = 0.029). Waist circumference and fasting blood glucose decreased across quartiles of habitual calcium intake (P = 0.04). In models that included MS (IDF) and PTH/25-OH-D3, the regression coefficients relating CIMT to PTH/25-OH-D3 ratio and MS were +51 µm (P = 0.013) and +19 µm (P = 0.45), respectively. Multivariable-adjusted analyses were confirmatory. Conclusions: MS prevalence and CIMT were positively associated with PTH/25-OH-D3. CIMT was not associated with MS. Prospective studies and intervention trials should address the causality of these associations. | - |
dc.description.sponsorship | The European Union (grants IC15-CT98-0329-EPOGH, LSHM-CT-2006-037093 InGenious HyperCare, and HEALTH-F4-2007-201550 HyperGenes), the Fonds voor Wetenschappelijk Onderzoek Vlaanderen, the Ministry of the Flemish Community, Brussels, Belgium (grants G.0575.06 and G.0734.09), and the University of Leuven, Leuven, Belgium (grants OT/00/25 and OT/05/49) gave support to the Studies Coordinating Centre. We gratefully acknowledge the expert assistance of Sandra Covens and Ya Zhu (Studies Coordinating Centre, Leuven, Belgium). We gratefully acknowledge the advice of Patrick Segers for the interpretation of arterial phenotypes(The Institute Biomedical Technology, Ghent University, Ghent, Belgium). | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.title | The Metabolic Syndrome and Carotid Intima-Media Thickness in Relation to the Parathyroid Hormone to 25-OH-D(3) Ratio in a General Population. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 109 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 102 | - |
dc.identifier.volume | 24 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Richart, Tom; Yu, Jin; Staessen, Jan A.] Maastricht Univ, Dept Epidemiol, Genet Epidemiol Unit, Maastricht, Netherlands.[Richart, Tom; Thijs, Lutgarde; Kuznetsova, Tatiana; Staessen, Jan A.] Univ Leuven, Studies Coordinating Ctr, Div Hypertens & Cardiovasc Rehabil, Dept Cardiovasc Dis, Louvain, Belgium. [Nawrot, Tim] Univ Hasselt, Lab Biol & Geol, Dept Chem Biol & Geol, Hasselt, Belgium. [Balkestein, Elisabeth J.; Struijker-Boudier, Harry A.] Maastricht Univ, Dept Pharmacol, Maastricht, Netherlands. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1038/ajh.2010.124 | - |
dc.identifier.isi | 000285501800017 | - |
item.validation | ecoom 2012 | - |
item.fulltext | No Fulltext | - |
item.fullcitation | Richart, Tom; Thijs, Lutgarde; NAWROT, Tim; Yu, Jin; Kuznetsova, Tatiana; Balkestein, Elisabeth J.; Struijker-Boudier, Harry A. & Staessen, Jan A. (2010) The Metabolic Syndrome and Carotid Intima-Media Thickness in Relation to the Parathyroid Hormone to 25-OH-D(3) Ratio in a General Population.. In: AMERICAN JOURNAL OF HYPERTENSION, 24(1). p. 102-109. | - |
item.accessRights | Closed Access | - |
item.contributor | Richart, Tom | - |
item.contributor | Thijs, Lutgarde | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Yu, Jin | - |
item.contributor | Kuznetsova, Tatiana | - |
item.contributor | Balkestein, Elisabeth J. | - |
item.contributor | Struijker-Boudier, Harry A. | - |
item.contributor | Staessen, Jan A. | - |
crisitem.journal.issn | 0895-7061 | - |
crisitem.journal.eissn | 1941-7225 | - |
Appears in Collections: | Research publications |
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