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Title: | Synthetic Exploration of Oxacalix[2]arene[2]quinazolines | Authors: | Van Rossom, Wim Kishore, Lingam Robeyns, Koen Van Meervelt, Luc Dehaen, Wim MAES, Wouter |
Issue Date: | 2010 | Publisher: | WILEY-V C H VERLAG GMBH | Source: | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (21). p. 4122-4129 | Abstract: | Oxacalix[2]arene[2]quinazoline macrocycles were prepared in good yields, as mixtures of syn and anti isomers, through nucleophilic aromatic substitution cyclocondensation reactions of 2,4-dichloroquinazolines and m-dihydroxybenzenes. The macrocyclization conditions were optimized and the isomeric ratio was investigated by means of one-step and fragment-coupling approaches. The oxacalixarene substitution pattern could easily be varied by altering the dichloroquinazolinyl biselectrophilic and dihydroxyaryl bisnucleophilic building blocks. The solid-state (1,3-alternate) conformational behavior and the oxacalix[4]arene cavity size were explored by X-ray diffraction studies. | Notes: | [Van Rossom, Wim; Kishore, Lingam; Robeyns, Koen; Van Meervelt, Luc; Dehaen, Wim; Maes, Wouter] Katholieke Univ Leuven, Dept Chem, B-3001 Louvain, Belgium. [Maes, Wouter] Hasselt Univ, Inst Mat Res IMO, Res Grp Organ & BioPolymer Chem, B-3590 Diepenbeek, Belgium. wim.dehaen@chem.kuleuven.be | Keywords: | Calixarenes; Nitrogen heterocycles; Aromatic substitution; Regioselectivity; Conformation analysis;Calixarenes; Nitrogen heterocycles; Aromatic substitution; Regioselectivity; Conformation analysis | Document URI: | http://hdl.handle.net/1942/11127 | ISSN: | 1434-193X | e-ISSN: | 1099-0690 | DOI: | 10.1002/ejoc.201000460 | ISI #: | 000280729500017 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2011 |
Appears in Collections: | Research publications |
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