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http://hdl.handle.net/1942/11218
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DC Field | Value | Language |
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dc.contributor.author | Gomez, Alejandro M. | - |
dc.contributor.author | Van den Broeck, Joost | - |
dc.contributor.author | Vrolix, Kathleen | - |
dc.contributor.author | Janssen, Sofie P. | - |
dc.contributor.author | Lemmens, Marijke A. M. | - |
dc.contributor.author | Van der Esch, Eline | - |
dc.contributor.author | Duimel, Hans | - |
dc.contributor.author | Frederik, Peter | - |
dc.contributor.author | Molenaar, Peter C. | - |
dc.contributor.author | Martinez-Martinez, Pilar | - |
dc.contributor.author | DE BAETS, Marc | - |
dc.contributor.author | Losen, Mario | - |
dc.date.accessioned | 2010-10-05T09:27:22Z | - |
dc.date.available | NO_RESTRICTION | - |
dc.date.available | 2010-10-05T09:27:22Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | AUTOIMMUNITY, 43 (5-6). p. 353-370 | - |
dc.identifier.issn | 0891-6934 | - |
dc.identifier.uri | http://hdl.handle.net/1942/11218 | - |
dc.description.abstract | Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies that are either directed to the muscle nicotinic acetylcholine receptor (AChR) or to the muscle-specific tyrosine kinase (MuSK). These autoantibodies define two distinct subforms of the disease-AChR-MG and MuSK-MG. Both AChR and MuSK arc expressed on the postsynaptic membrane of the neuromuscular junction (NMJ), which is a highly specialized region of the muscle dedicated to receive and process signals from the motor nerve. Autoantibody binding to proteins of the postsynaptic membrane leads to impaired neuromuscular transmission and muscle weakness. Pro-inflammatory antibodies of the human IgG1 and IgG3 subclass modulate the AChR, cause complement activation, and attract lymphocytes; together acting to decrease levels of the AChR and AChR-associated proteins and to reduce postsynaptic folding. In patients with anti-MuSK antibodies, there is no evidence of loss of junctional folds and no apparent loss of AChR density. Anti-MuSK antibodies are predominantly of the IgG4 isotype, which functionally differs from other IgG subclasses in its anti-inflammatory activity. Moreover, IgG4 undergoes a posttranslational modification termed Fab arm exchange that prevents cross-linking of antigens. These findings suggest that MuSK-MG may be different in etiological and pathological mechanisms from AChR-MG. The effector functions of IgG subclasses on synapse structure and function are discussed in this review. | - |
dc.description.sponsorship | The micrographs in this paper were taken with a confocal spinning disk microscope financed by The Netherlands Organisation for Scientific Research (NWO), grant number 911-06-003. The authors' experimental work was supported by grants from the Prinses Beatrix Fonds, L'Association Francaise contre les Myopathies, the European Union Sixth Framework Program (FP6) MYASTAID LSHM-CT-2006-037833, Genmab and Aspreva. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject.other | Myasthenia gravis; neuromuscular junction; IgG4; Fab arm exchange; complement | - |
dc.subject.other | Myasthenia gravis; neuromuscular junction; IgG4; Fab arm exchange; complement | - |
dc.title | Antibody effector mechanisms in myasthenia gravis-Pathogenesis at the neuromuscular junction | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 370 | - |
dc.identifier.issue | 5-6 | - |
dc.identifier.spage | 353 | - |
dc.identifier.volume | 43 | - |
local.format.pages | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Gomez, Alejandro M.; Van den Broeck, Joost; Vrolix, Kathleen; Janssen, Sofie P.; Lemmens, Marijke A. M.; Van der Esch, Eline; Molenaar, Peter C.; Martinez-Martinez, Pilar; De Baets, Marc H.; Losen, Mario] Univ Maastricht, Dept Neurosci, Sch Mental Hlth & Neurosci, Neuroimmunol Grp, NL-6200 MD Maastricht, Netherlands. [Duimel, Hans; Frederik, Peter] Maastricht Univ, Electron Microscopy Unit, Dept Pathol, Maastricht, Netherlands. [De Baets, Marc H.] Hasselt Univ, Biomed Res Inst BIOMED, Neuroimmunol Grp, Diepenbeek, Belgium. m.losen@maastrichtuniversity.nl | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.3109/08916930903555943 | - |
dc.identifier.isi | 000281961100003 | - |
item.accessRights | Closed Access | - |
item.validation | ecoom 2011 | - |
item.fulltext | No Fulltext | - |
item.fullcitation | Gomez, Alejandro M.; Van den Broeck, Joost; Vrolix, Kathleen; Janssen, Sofie P.; Lemmens, Marijke A. M.; Van der Esch, Eline; Duimel, Hans; Frederik, Peter; Molenaar, Peter C.; Martinez-Martinez, Pilar; DE BAETS, Marc & Losen, Mario (2010) Antibody effector mechanisms in myasthenia gravis-Pathogenesis at the neuromuscular junction. In: AUTOIMMUNITY, 43 (5-6). p. 353-370. | - |
item.contributor | Gomez, Alejandro M. | - |
item.contributor | Van den Broeck, Joost | - |
item.contributor | Vrolix, Kathleen | - |
item.contributor | Janssen, Sofie P. | - |
item.contributor | Lemmens, Marijke A. M. | - |
item.contributor | Van der Esch, Eline | - |
item.contributor | Duimel, Hans | - |
item.contributor | Frederik, Peter | - |
item.contributor | Molenaar, Peter C. | - |
item.contributor | Martinez-Martinez, Pilar | - |
item.contributor | DE BAETS, Marc | - |
item.contributor | Losen, Mario | - |
crisitem.journal.issn | 0891-6934 | - |
crisitem.journal.eissn | 1607-842X | - |
Appears in Collections: | Research publications |
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