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Title: Polymorphisms in CACNA1 E and Camk2d are associated with seizure susceptibility of Sprague-Dawley rats
Authors: Rijkers, Kim
Mescheriakova, Julia
Majoie, Marian
van Wijk, Xander
Philippens, Marjan
Van Kranen-Mastenbroek, Vivianne
Schijns, Olaf
Vles, Johannes
Hoogland, Govert
Issue Date: 2010
Source: EPILEPSY RESEARCH, 91 (1). p. 28-34
Abstract: Seizures are associated with high intracellular calcium levels. However, conditions characterized by high intracellular calcium levels, such as stroke or traumatic brain injury, do not always evoke epilepsy. We hypothesized that polymorphisms in calcium-related genes CACNA1E and Camk2d contribute to the individual variability in seizure susceptibility. The distribution of one single nucleotide polymorphism (SNP) in the CACNA1E and one in the Camk2d gene was determined in Sprague-Dawley rats that were subjected to amygdala kindling or hyperthermia-induced seizures. The pre-kindling afterdischarge threshold was significantly lower in rats with the CACNA1E GG genotype (45.2 +/- 6.7 mu A) than in the GT genotyped animals (79.3 +/- 53.7 mu A). Among hyperthermia treated rats, the Camk2d G allele was more frequent among rats that did not display behavioral seizures during hyperthermia (67%) than in animals that did show behavioral seizures during hyperthermia (52%, chi(2)(1) = 3.847, p = 0.05). SNPs in CACNA1E and Camk2d genes are associated with the individual variability in seizure susceptibility in two experimental seizure models. (C) 2010 Elsevier B.V. All rights reserved.
Notes: [Rijkers, Kim; Mescheriakova, Julia; Lemmens, Evi; van Wijk, Xander; Philippens, Marjan; Schijns, Olaf; Hoogland, Govert] Univ Med Ctr Maastricht, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands. [Rijkers, Kim; Lemmens, Evi; Hoogland, Govert] European Grad Sch Neurosci EURON, Heeze, Netherlands. [Majoie, Marian] Univ Med Ctr Maastricht, Dept Neurol, NL-6202 AZ Maastricht, Netherlands. [Majoie, Marian] Epilepsy Ctr Kempenhaeghe, Heeze, Netherlands. [Lemmens, Evi] Hasselt Univ, Diepenbeek, Belgium. [Van Kranen-Mastenbroek, Vivianne] Univ Med Ctr Maastricht, Dept Clin Neurophysiol, NL-6202 AZ Maastricht, Netherlands. [Vles, Johannes] Univ Med Ctr Maastricht, Dept Child Neurol, NL-6202 AZ Maastricht, Netherlands.
Keywords: Polymorphisms; Kindling; Hyperthermia; Seizures;Polymorphisms; Kindling; Hyperthermia; Seizures
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ISSN: 0920-1211
e-ISSN: 1872-6844
DOI: 10.1016/j.eplepsyres.2010.06.006
ISI #: 000282619100004
Category: A1
Type: Journal Contribution
Validations: ecoom 2011
Appears in Collections:Research publications

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