Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11432
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dc.contributor.authorBUYSE, Marc-
dc.date.accessioned2011-01-06T17:20:57Z-
dc.date.availableNO_RESTRICTION-
dc.date.available2011-01-06T17:20:57Z-
dc.date.issued2009-
dc.identifier.citationINTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 14 (2). p. 95-101-
dc.identifier.issn1341-9625-
dc.identifier.urihttp://hdl.handle.net/1942/11432-
dc.description.abstractMeta-analysis is the statistical process of combining information from several studies addressing the same question. Meta-analyses based on individual patient data are far more reliable and informative than those based on summary statistics obtained from the trialists or extracted from the published literature. Meta-analysis of randomized clinical trials may contribute to therapeutic progress through (1) establishing efficacy benefits beyond a reasonable doubt, (2) identifying sources of heterogeneity between trials, (3) studying subsets reliably, (4) confirming differences in toxicity profiles, (5) evaluating the cost-effectiveness of experimental therapies, (6) assessing surrogate endpoints, and (7) addressing ancillary questions. All of these potential contributions are illustrated with examples in early and advanced colorectal cancer.-
dc.language.isoen-
dc.publisherSPRINGER TOKYO-
dc.subject.otherMeta-analysis; Colorectal cancer-
dc.subject.otherMeta-analysis; Colorectal cancer-
dc.titleContributions of meta-analyses based on individual patient data to therapeutic progress in colorectal cancer-
dc.typeJournal Contribution-
dc.identifier.epage101-
dc.identifier.issue2-
dc.identifier.spage95-
dc.identifier.volume14-
local.format.pages7-
local.bibliographicCitation.jcatA1-
dc.description.notes[Buyse, Marc] Int Inst Drug Dev, Louvain, Belgium. [Buyse, Marc] Hasselt Univ, Ctr Stat, Diepenbeek, Belgium. marc.buyse@iddi.com-
local.type.refereedRefereed-
local.type.specifiedReview-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1007/s10147-009-0879-2-
dc.identifier.isi000265498500004-
item.fullcitationBUYSE, Marc (2009) Contributions of meta-analyses based on individual patient data to therapeutic progress in colorectal cancer. In: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 14 (2). p. 95-101.-
item.fulltextNo Fulltext-
item.contributorBUYSE, Marc-
item.validationecoom 2010-
item.accessRightsClosed Access-
crisitem.journal.issn1341-9625-
crisitem.journal.eissn1437-7772-
Appears in Collections:Research publications
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