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http://hdl.handle.net/1942/11432
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DC Field | Value | Language |
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dc.contributor.author | BUYSE, Marc | - |
dc.date.accessioned | 2011-01-06T17:20:57Z | - |
dc.date.available | NO_RESTRICTION | - |
dc.date.available | 2011-01-06T17:20:57Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 14 (2). p. 95-101 | - |
dc.identifier.issn | 1341-9625 | - |
dc.identifier.uri | http://hdl.handle.net/1942/11432 | - |
dc.description.abstract | Meta-analysis is the statistical process of combining information from several studies addressing the same question. Meta-analyses based on individual patient data are far more reliable and informative than those based on summary statistics obtained from the trialists or extracted from the published literature. Meta-analysis of randomized clinical trials may contribute to therapeutic progress through (1) establishing efficacy benefits beyond a reasonable doubt, (2) identifying sources of heterogeneity between trials, (3) studying subsets reliably, (4) confirming differences in toxicity profiles, (5) evaluating the cost-effectiveness of experimental therapies, (6) assessing surrogate endpoints, and (7) addressing ancillary questions. All of these potential contributions are illustrated with examples in early and advanced colorectal cancer. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER TOKYO | - |
dc.subject.other | Meta-analysis; Colorectal cancer | - |
dc.subject.other | Meta-analysis; Colorectal cancer | - |
dc.title | Contributions of meta-analyses based on individual patient data to therapeutic progress in colorectal cancer | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 101 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 95 | - |
dc.identifier.volume | 14 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Buyse, Marc] Int Inst Drug Dev, Louvain, Belgium. [Buyse, Marc] Hasselt Univ, Ctr Stat, Diepenbeek, Belgium. marc.buyse@iddi.com | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1007/s10147-009-0879-2 | - |
dc.identifier.isi | 000265498500004 | - |
item.fullcitation | BUYSE, Marc (2009) Contributions of meta-analyses based on individual patient data to therapeutic progress in colorectal cancer. In: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 14 (2). p. 95-101. | - |
item.fulltext | No Fulltext | - |
item.contributor | BUYSE, Marc | - |
item.validation | ecoom 2010 | - |
item.accessRights | Closed Access | - |
crisitem.journal.issn | 1341-9625 | - |
crisitem.journal.eissn | 1437-7772 | - |
Appears in Collections: | Research publications |
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