Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11451
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dc.contributor.authorStalmans, Ingeborg-
dc.contributor.authorSiesky, Brent-
dc.contributor.authorZeyen, Thierry-
dc.contributor.authorFIEUWS, Steffen-
dc.contributor.authorHarris, Alon-
dc.date.accessioned2011-01-06T18:00:58Z-
dc.date.availableNO_RESTRICTION-
dc.date.available2011-01-06T18:00:58Z-
dc.date.issued2009-
dc.identifier.citationGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 247(11). p. 1531-1538-
dc.identifier.issn0721-832X-
dc.identifier.urihttp://hdl.handle.net/1942/11451-
dc.description.abstractThe aims of this study were: (1) to determine the intra-subject and inter-observer variability of color Doppler imaging (CDI) measurements and readings of the retrobulbar blood vessels, (2) to compare the difference in variability of CDI parameters in non-glaucomatous controls versus glaucoma patients, and (3) to provide calculations of minimum sample sizes for future CDI studies. Patients with normal tension glaucoma (n = 28), primary open-angle glaucoma (n = 19) and non-glaucomatous controls of comparable age (n = 22) underwent CDI on two occasions 1 month apart. Variability in CDI parameters was quantified using (within-subject) coefficients of variation. Based on this variability, minimum sample sizes were calculated to guide the design of future studies comparing CDI between and within groups. In general, within-subject coefficients of variation for measurements 1 month apart were comparable to previously reported short-term variations. Variability was higher in glaucoma patients than in non-glaucomatous controls. The minimum sample size required for glaucomatous study populations is larger than for non-glaucomatous controls. Smaller patient groups are required to detect change using the peak systolic blood flow velocities than using end diastolic velocities. Studies using a cross-over design require smaller sample sizes than studies with a pre-post or particularly parallel design. This study provides extensive information on long-term intra-subject variability of CDI measurements in non-glaucomatous controls as well as glaucoma patients. Moreover, sample size calculations are provided for studies involving glaucoma patients as well as non-glaucomatous individuals, using three different commonly used study designs.-
dc.language.isoen-
dc.publisherSPRINGER-
dc.subject.otherColor Doppler imaging; Glaucoma; Blood flow; Reproducibility-
dc.subject.otherColor Doppler imaging; Glaucoma; Blood flow; Reproducibility-
dc.titleReproducibility of color Doppler imaging-
dc.typeJournal Contribution-
dc.identifier.epage1538-
dc.identifier.issue11-
dc.identifier.spage1531-
dc.identifier.volume247-
local.format.pages8-
local.bibliographicCitation.jcatA1-
dc.description.notes[Stalmans, Ingeborg; Zeyen, Thierry] Univ Hosp Leuven, Dept Ophthalmol, B-3000 Louvain, Belgium. [Siesky, Brent; Harris, Alon] Indiana Univ, Sch Med, Dept Ophthalmol, Indianapolis, IN 46202 USA. [Fieuws, Steffen] Catholic Univ Louvain, B-3000 Louvain, Belgium. [Fieuws, Steffen] Univ Hasselt, B-3000 Louvain, Belgium. ingeborg.stalmans@uzleuven.be; steffen.fieuws@med.kuleuven.be; alharris@indiana.edu-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
local.classIncludeIn-ExcludeFrom-List/ExcludeFromFRIS-
dc.identifier.doi10.1007/s00417-009-1178-3-
dc.identifier.isi000270541500010-
item.fullcitationStalmans, Ingeborg; Siesky, Brent; Zeyen, Thierry; FIEUWS, Steffen & Harris, Alon (2009) Reproducibility of color Doppler imaging. In: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 247(11). p. 1531-1538.-
item.fulltextNo Fulltext-
item.accessRightsClosed Access-
item.validationecoom 2010-
item.contributorStalmans, Ingeborg-
item.contributorSiesky, Brent-
item.contributorZeyen, Thierry-
item.contributorFIEUWS, Steffen-
item.contributorHarris, Alon-
crisitem.journal.issn0721-832X-
crisitem.journal.eissn1435-702X-
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