Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11469
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dc.contributor.authorLeonard, Daniel-
dc.contributor.authorPenninckx, Freddy-
dc.contributor.authorFIEUWS, Steffen-
dc.contributor.authorJouret-Mourin, Anne-
dc.contributor.authorSempoux, Christine-
dc.contributor.authorJehaes, Constant-
dc.contributor.authorVan Eycken, Elizabeth-
dc.date.accessioned2011-01-09T08:32:25Z-
dc.date.availableNO_RESTRICTION-
dc.date.available2011-01-09T08:32:25Z-
dc.date.issued2010-
dc.identifier.citationANNALS OF SURGERY, 252 (6). p. 982-988-
dc.identifier.issn0003-4932-
dc.identifier.urihttp://hdl.handle.net/1942/11469-
dc.description.abstractObjective: To determine preoperative tumor-, patient-, and treatment-related factors that are independently associated with incomplete mesorectal excision. Summary of Background Data: Incomplete total mesorectal excision (TME) for rectal cancer is associated with increased local and overall recurrences. Factors predicting incomplete mesorectal excision have scarcely been studied. Methods: In the context of PROCARE, a Belgian multidisciplinary project on rectal cancer, the quality of 266 consecutive and anonymized TME specimens submitted by 33 candidate-TME-trainers was graded by a blinded pathology review board in a standardized manner. Uni- and multivariable analysis were performed to identify factors that can independently predict incomplete mesorectal excision. Results: Mesorectal resection was complete in 21%, nearly complete in 47%, and incomplete in 32%. Of 57% of TME specimens the grade of resection had not been reported by the local pathologist. Incomplete TME doubled the incidence of a positive circumferential resection margin (P = 0.004). Factors found to be significantly related to incomplete TME in univariate analysis were as follows: surgeon, female gender, pathologic body mass index, low rectal cancer, negative clinical nodal status, the absence of downstaging after long-course chemoradiation, laparoscopic and converted laparoscopic resection, and abdominoperineal resection. Multivariable analysis identified pathologic body mass index (P = 0.017), the absence of downstaging after long-course chemoradiation (P = 0.0005), and laparoscopic or converted laparoscopic resection (P = 0.014) as factors that are independently associated with incomplete mesorectal excision. Conclusion: Good TME quality cannot be guaranteed. This peer-reviewed TME assessment revealed a number of factors that are independently related to incomplete TME. Both specimen and pathology report need to be audited.-
dc.description.sponsorshipSupported by the Belgian Ministry of Social Affairs.-
dc.language.isoen-
dc.publisherLIPPINCOTT WILLIAMS & WILKINS-
dc.titleFactors Predicting the Quality of Total Mesorectal Excision for Rectal Cancer-
dc.typeJournal Contribution-
dc.identifier.epage988-
dc.identifier.issue6-
dc.identifier.spage982-
dc.identifier.volume252-
local.format.pages7-
local.bibliographicCitation.jcatA1-
dc.description.notes[Penninckx, Freddy] Univ Clin Gasthuisberg, Dept Abdominal Surg, B-3000 Louvain, Belgium. [Leonard, Daniel] St Luc Univ Hosp, Dept Surg & Abdominal Transplantat, Colorectal Surg Unit, Brussels, Belgium. [Fieuws, Steffen] Katholieke Univ Leuven, Dept Biostat 1, Louvain, Belgium. [Fieuws, Steffen] Univ Hasselt, Hasselt, Belgium. [Jouret-Mourin, Anne; Sempoux, Christine] St Luc Univ Hosp, Dept Pathol, Brussels, Belgium. [Jehaes, Constant] Clin St Joseph CHC, Dept Abdominal Surg, Liege, Belgium. [Van Eycken, Elizabeth] Belgian Canc Registry, Brussels, Belgium. freddy.penninckx@uz.kuleuven.ac.be-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1097/SLA.0b013e3181efc142-
dc.identifier.isi000284603800013-
item.fulltextNo Fulltext-
item.accessRightsClosed Access-
item.validationecoom 2011-
item.fullcitationLeonard, Daniel; Penninckx, Freddy; FIEUWS, Steffen; Jouret-Mourin, Anne; Sempoux, Christine; Jehaes, Constant & Van Eycken, Elizabeth (2010) Factors Predicting the Quality of Total Mesorectal Excision for Rectal Cancer. In: ANNALS OF SURGERY, 252 (6). p. 982-988.-
item.contributorJouret-Mourin, Anne-
item.contributorVan Eycken, Elizabeth-
item.contributorPenninckx, Freddy-
item.contributorLeonard, Daniel-
item.contributorSempoux, Christine-
item.contributorJehaes, Constant-
item.contributorFIEUWS, Steffen-
crisitem.journal.issn0003-4932-
crisitem.journal.eissn1528-1140-
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