Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11550
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dc.contributor.authorVENKEN, Koen-
dc.contributor.authorHELLINGS, Niels-
dc.contributor.authorHENSEN, Karen-
dc.contributor.authorRUMMENS, Jean-Luc-
dc.contributor.authorSTINISSEN, Piet-
dc.date.accessioned2011-01-26T13:27:00Z-
dc.date.availableNO_RESTRICTION-
dc.date.available2011-01-26T13:27:00Z-
dc.date.issued2010-
dc.identifier.citationJOURNAL OF NEUROIMMUNOLOGY, 226 (1-2). p. 185-191-
dc.identifier.issn0165-5728-
dc.identifier.urihttp://hdl.handle.net/1942/11550-
dc.description.abstractMyelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MUG) and tetanus toxoid (TT). Proliferative responses of Tconv cells towards MBP, MUG and TT were not significantly different between MS patients and HC. However, MBP and MUG but not TT reactive memory Tconv cells from MS patients, in contrast to HC, produced IL-17. These results suggest that myelin antigen reactive Th-17 cells are enriched in MS patients. (C) 2010 Elsevier B.V. All rights reserved.-
dc.description.sponsorshipThis study was supported by research funding from the Belgian Charchot Foundation, Hasselt University and Transnational University Limburg. The authors would like to thank Dr. R. Medaer, Dr. B. Van Wijmeersch and A. Bogaers for blood collections and all MS patients and volunteers included in this study for blood donations. We also thank Hanne Jongen for professional help with FACS-sorting of T cell subsets.-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE BV-
dc.subject.otherMultiple sclerosis; Myelin-reactive T cells; T helper-17 cells-
dc.titleMemory CD4(+)CD127(high) T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens-
dc.typeJournal Contribution-
dc.identifier.epage191-
dc.identifier.issue1-2-
dc.identifier.spage185-
dc.identifier.volume226-
local.format.pages7-
local.bibliographicCitation.jcatA1-
dc.description.notes[Venken, Koen] Ghent Univ Hosp, Dept Rheumatol, Lab Mol Immunol & Inflammat, B-9000 Ghent, Belgium. [Venken, Koen; Hellings, Niels; Stinissen, Piet] Hasselt Univ, Biomed Onderzoeksinst, Diepenbeek, Belgium. [Venken, Koen; Hellings, Niels; Stinissen, Piet] Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [Hensen, Karen; Rummens, Jean-Luc] Virga Jesse Hosp, Clin Lab Expt Hematol, Hasselt, Belgium. koen.venken@ugent.be-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1016/j.jneuroim.2010.05.025-
dc.identifier.isi000282545500026-
item.contributorVENKEN, Koen-
item.contributorHELLINGS, Niels-
item.contributorHENSEN, Karen-
item.contributorRUMMENS, Jean-Luc-
item.contributorSTINISSEN, Piet-
item.validationecoom 2012-
item.fullcitationVENKEN, Koen; HELLINGS, Niels; HENSEN, Karen; RUMMENS, Jean-Luc & STINISSEN, Piet (2010) Memory CD4(+)CD127(high) T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens. In: JOURNAL OF NEUROIMMUNOLOGY, 226 (1-2). p. 185-191.-
item.accessRightsRestricted Access-
item.fulltextWith Fulltext-
crisitem.journal.issn0165-5728-
crisitem.journal.eissn1872-8421-
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