Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/11601
Title: | Generalized pairwise comparisons of prioritized outcomes in the two-sample problem | Authors: | BUYSE, Marc | Issue Date: | 2010 | Publisher: | JOHN WILEY & SONS LTD | Source: | STATISTICS IN MEDICINE, 29 (30). p. 3245-3257 | Abstract: | This paper extends the idea behind the U-statistic of the Wilcoxon-Mann-Whitney test to perform generalized pairwise comparisons between two groups of observations. The observations are outcomes captured by a single variable, possibly repeatedly measured, or by several variables of any type (e.g. discrete, continuous, time to event). When several outcomes are considered, they must be prioritized. We show that generalized pairwise comparisons extend well-known non-parametric tests, and illustrate their interest using data from two randomized clinical trials. We also show that they lead to a general measure of the difference between the groups called the 'proportion in favor of treatment', denoted Delta, which is related to traditional measures of treatment effect for a single variable. Copyright (C) 2010 John Wiley & Sons, Ltd. | Notes: | [Buyse, Marc] Int Inst Drug Dev, B-1340 Louvain, Belgium. [Buyse, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BioSt, Hasselt, Belgium. marc.buyse@iddi.com | Keywords: | generalized pairwise comparisons; prioritized outcomes; measure of treatment effect; randomization test;generalized pairwise comparisons; prioritized outcomes; measure of treatment effect; randomization test | Document URI: | http://hdl.handle.net/1942/11601 | ISSN: | 0277-6715 | e-ISSN: | 1097-0258 | DOI: | 10.1002/sim.3923 | ISI #: | 000285846300017 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2012 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
buyse 1.pdf Restricted Access | Published version | 167.21 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.