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http://hdl.handle.net/1942/11727
Title: | Cost-effectiveness of varicella and zoster vaccination in England & Wales: importance measures for correlated parameters | Authors: | Bilcke, Joke Van Hoek, Albert-Jan HENS, Niel AERTS, Marc Edmunds, John Beutels, Philippe |
Issue Date: | 2010 | Publisher: | Elsevier | Source: | Procedia Social and Behavioral Sciences, 6, p. 7611-7612 | Series/Report: | Procedia Social and Behavioral Sciences | Series/Report no.: | 6 | Abstract: | This study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R² was calculated for groups of interdependent input parameters. Partial R² was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R² is an easy to obtain importance measure, also in the presence of interdependent input parameters. | Keywords: | coefficient of determination; correlation; dependency; sensitivity measure; uncertainty; cost-effectiveness | Document URI: | http://hdl.handle.net/1942/11727 | DOI: | 10.1016/j.sbspro.2010.05.142 | Category: | C1 | Type: | Proceedings Paper |
Appears in Collections: | Research publications |
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Bilcke_et_al_2010[1].pdf | 217.5 kB | Adobe PDF | View/Open |
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