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Title: Cost-effectiveness of varicella and zoster vaccination in England & Wales: importance measures for correlated parameters
Authors: Bilcke, Joke
Van Hoek, Albert-Jan
HENS, Niel 
AERTS, Marc 
Edmunds, John
Beutels, Philippe
Issue Date: 2010
Publisher: Elsevier
Source: Procedia Social and Behavioral Sciences, 6, p. 7611-7612
Series/Report: Procedia Social and Behavioral Sciences
Series/Report no.: 6
Abstract: This study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R² was calculated for groups of interdependent input parameters. Partial R² was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R² is an easy to obtain importance measure, also in the presence of interdependent input parameters.
Keywords: coefficient of determination; correlation; dependency; sensitivity measure; uncertainty; cost-effectiveness
Document URI:
DOI: 10.1016/j.sbspro.2010.05.142
Category: C1
Type: Proceedings Paper
Appears in Collections:Research publications

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