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http://hdl.handle.net/1942/11880
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DC Field | Value | Language |
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dc.contributor.author | OGUNJIMI, Benson | - |
dc.contributor.author | Smits, Evelien | - |
dc.contributor.author | HENS, Niel | - |
dc.contributor.author | Hens, Annick | - |
dc.contributor.author | Lenders, Kevin | - |
dc.contributor.author | Ieven, Margareta | - |
dc.contributor.author | Van Tendeloo, Viggo | - |
dc.contributor.author | Van Damme, Pierre | - |
dc.contributor.author | Beutels, Philippe | - |
dc.date.accessioned | 2011-04-27T08:19:10Z | - |
dc.date.available | NO_RESTRICTION | - |
dc.date.available | 2011-04-27T08:19:10Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | VIRAL IMMUNOLOGY, 24(2). p. 151-157 | - |
dc.identifier.issn | 0882-8245 | - |
dc.identifier.uri | http://hdl.handle.net/1942/11880 | - |
dc.description.abstract | Varicella-zoster virus (VZV) causes both primary varicella, and through reactivation of the virus, herpes zoster. It is hypothesized that VZV-immune adults may reduce the probability of developing herpes zoster through exposure to varicella. In this study we examine the existence of immunological boosting in VZV-immune adults after close contact with primary varicella. We followed-up 18 parents with household exposure to primary varicella for 1 y. Fifteen age-matched healthy and 20 older volunteers served as control groups. Cellular (IFN-gamma ELISPOT) and humoral responses were measured. Data analyses were performed by t-tests and linear mixed models. The young control group only showed higher cellular responses than the older control group and the exposed group 1 mo after exposure. The exposed group had a strong tendency toward higher cellular responses compared to the older control group, reaching significance 1 y post-exposure. The best fitting linear mixed model predicts a decline in cellular response of 50% between 1 wk and 1 mo post-exposure, followed by an increase to attain an 80% higher level at 1 y compared to the first week post-exposure. No significant results emerged based on the humoral response of the individual parents in the exposed group, despite a general tendency toward higher antibody concentrations in the exposed versus the control groups. No significant difference in humoral immunity was found between the control groups. One year after initial re-exposure to VZV, VZV-immune adults showed a rise in cellular response as assessed by IFN-g ELISPOT, and steady-state levels for the humoral response. | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT INC | - |
dc.title | Exploring the Impact of Exposure to Primary Varicella in Children on Varicella-Zoster Virus Immunity of Parents | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 157 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 151 | - |
dc.identifier.volume | 24 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Ogunjimi, Benson] Univ Antwerp, Fac Med, Vaccine & Infect Dis Inst, CHERMID, B-2610 Antwerp, Belgium. [Ogunjimi, Benson; Hens, Niel; Hens, Annick; Van Damme, Pierre; Beutels, Philippe] Univ Antwerp, Vaccine & Infect Dis Inst, CEV, B-2610 Antwerp, Belgium. [Smits, Evelien; Lenders, Kevin; Van Tendeloo, Viggo] Univ Antwerp, Vaccine & Infect Dis Inst, Lab Expt Hematol, B-2610 Antwerp, Belgium. [Ieven, Margareta] Univ Antwerp, Vaccine & Infect Dis Inst, Dept Microbiol, B-2610 Antwerp, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Beutels, Philippe] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1089/vim.2010.0031 | - |
dc.identifier.isi | 000288983000010 | - |
item.fullcitation | OGUNJIMI, Benson; Smits, Evelien; HENS, Niel; Hens, Annick; Lenders, Kevin; Ieven, Margareta; Van Tendeloo, Viggo; Van Damme, Pierre & Beutels, Philippe (2011) Exploring the Impact of Exposure to Primary Varicella in Children on Varicella-Zoster Virus Immunity of Parents. In: VIRAL IMMUNOLOGY, 24(2). p. 151-157. | - |
item.fulltext | No Fulltext | - |
item.validation | ecoom 2012 | - |
item.contributor | OGUNJIMI, Benson | - |
item.contributor | Smits, Evelien | - |
item.contributor | HENS, Niel | - |
item.contributor | Hens, Annick | - |
item.contributor | Lenders, Kevin | - |
item.contributor | Ieven, Margareta | - |
item.contributor | Van Tendeloo, Viggo | - |
item.contributor | Van Damme, Pierre | - |
item.contributor | Beutels, Philippe | - |
item.accessRights | Closed Access | - |
crisitem.journal.issn | 0882-8245 | - |
crisitem.journal.eissn | 1557-8976 | - |
Appears in Collections: | Research publications |
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