Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12013
Title: LATE VITAMIN K DEFICIENCY BLEEDING LEADING TO A DIAGNOSIS OF CYSTIC FIBROSIS: A CASE REPORT
Authors: Ngo, B.
Van Pelt, K.
Labarque, V
Van De Casseye, W.
PENDERS, Joris 
Issue Date: 2011
Publisher: ACTA CLINICA BELGICA
Source: ACTA CLINICA BELGICA, 66(2). p. 142-143
Abstract: Vitamin K deficiency bleeding (VKDB) in infants still occurs despite worldwide use of prophylaxis. Clinical manifestations can be dramatic with over 50% of patients presenting with intracranial haemorrhage and a mortality rate of 20% in late vitamin K deficiency bleeding. Special attention should be given to infants with a high risk profile (preterm, breast feeding, cholestasis, malabsorption). A tentative diagnosis can be made observing quick normalisation of some easy-to-perform haemostatic parameters (PT, aPTT) after administration of vitamin K. Nowadays, VKDB can still be the first clinical sign of diseases causing malabsorption of fat-soluble vitamins. In this case report, VKDB led to the diagnosis of cystic fibrosis, the most common fatal autosomal recessive disease among Caucasian people.
Notes: [Ngo, B.; Van Pelt, K.; Van De Casseye, W.; Penders, J.] Ziekenhuis Oost Limburg, Lab Clin Biol, Genk, Belgium. [Labarque, V] UZ Leuven, Dept Paediat Haematooncol, Leuven, Belgium. [Van De Casseye, W.] UZ Leuven, Dept Paediat, Leuven, Belgium. [Penders, J.] Hasselt Univ, Fac Med, Diepenbeek, Belgium.
Keywords: Vitamin K deficiency bleeding; cystic fibrosis; haemorrhagic disease of the newborn
Document URI: http://hdl.handle.net/1942/12013
ISSN: 0001-5512
DOI: 10.2143/ACB.66.2.2062536
ISI #: 000290931300012
Category: A1
Type: Journal Contribution
Validations: ecoom 2012
Appears in Collections:Research publications

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