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Title: | LATE VITAMIN K DEFICIENCY BLEEDING LEADING TO A DIAGNOSIS OF CYSTIC FIBROSIS: A CASE REPORT | Authors: | Ngo, B. Van Pelt, K. Labarque, V Van De Casseye, W. PENDERS, Joris |
Issue Date: | 2011 | Publisher: | ACTA CLINICA BELGICA | Source: | ACTA CLINICA BELGICA, 66(2). p. 142-143 | Abstract: | Vitamin K deficiency bleeding (VKDB) in infants still occurs despite worldwide use of prophylaxis. Clinical manifestations can be dramatic with over 50% of patients presenting with intracranial haemorrhage and a mortality rate of 20% in late vitamin K deficiency bleeding. Special attention should be given to infants with a high risk profile (preterm, breast feeding, cholestasis, malabsorption). A tentative diagnosis can be made observing quick normalisation of some easy-to-perform haemostatic parameters (PT, aPTT) after administration of vitamin K. Nowadays, VKDB can still be the first clinical sign of diseases causing malabsorption of fat-soluble vitamins. In this case report, VKDB led to the diagnosis of cystic fibrosis, the most common fatal autosomal recessive disease among Caucasian people. | Notes: | [Ngo, B.; Van Pelt, K.; Van De Casseye, W.; Penders, J.] Ziekenhuis Oost Limburg, Lab Clin Biol, Genk, Belgium. [Labarque, V] UZ Leuven, Dept Paediat Haematooncol, Leuven, Belgium. [Van De Casseye, W.] UZ Leuven, Dept Paediat, Leuven, Belgium. [Penders, J.] Hasselt Univ, Fac Med, Diepenbeek, Belgium. | Keywords: | Vitamin K deficiency bleeding; cystic fibrosis; haemorrhagic disease of the newborn | Document URI: | http://hdl.handle.net/1942/12013 | ISSN: | 0001-5512 | DOI: | 10.2143/ACB.66.2.2062536 | ISI #: | 000290931300012 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2012 |
Appears in Collections: | Research publications |
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