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http://hdl.handle.net/1942/12566
Title: | Minocycline-conditioning brings surveying and reactive microglial cells to an alerted state according to their potassium channel profile | Authors: | Dries, Eef | Advisors: | BRONE, Bert RIGO, Jean-Michel |
Issue Date: | 2010 | Publisher: | tUL Diepenbeek | Abstract: | Microglial cells, the macrophages of the central nervous system (CNS), are key players during inflammatory processes in the CNS and are characterized by the expression of several types of voltage-gated potassium (Kv) channels, such as the delayed rectifying potassium (Kdr) current in reactive microglial cells. This Kdr current has been reported as a physiological marker for microglial activation and is an important target to control microglial activities. In this study we investigated whether minocycline, a known microglial activation inhibitor, was able to inhibit the functional expression of this Kdr current. Therefore, the I/V relationships and the function of the Kv channels of primary cultured rat microglial cells were measured using the whole-cell patch-clamp technique. The I/V profiles were compared in control and lipopolysaccharide (LPS)-activated (100 ng/ml) microglial cells in absence and presence of minocycline (400 µg/ml). | Notes: | master in de biomedische wetenschappen-klinische moleculaire wetenschappen | Document URI: | http://hdl.handle.net/1942/12566 | Category: | T2 | Type: | Theses and Dissertations |
Appears in Collections: | Master theses |
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05232642009249.pdf | 1.47 MB | Adobe PDF | View/Open |
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