Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12803
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dc.contributor.advisorHELLINGS, Niels-
dc.contributor.authorBrulmans, Marijke-
dc.date.accessioned2011-11-25T09:06:56Z-
dc.date.available2011-11-25T09:06:56Z-
dc.date.issued2011-
dc.identifier.urihttp://hdl.handle.net/1942/12803-
dc.description.abstractDuring aging and chronic infections, T cells lose the costimulatory molecule CD28 and show various similarities with NK cells, such as proinflammatory functions characterized by the production of high levels of IFN-gamma, TNF-alpha, and IL-2. They are cytotoxic and resistant to apoptotic cell death. An increase in CD4+CD28null T cells represents an important amplification mechanism in several autoimmune diseases, leading to more severe disease symptoms. CD8+CD28null T cells are also detrimental for the host, but have been shown to have some beneficial effects as well. We aim to further elucidate the role of both CD8+CD28null and CD4+CD28null T cells in immunopathology, and hypothesize that CD4+CD28null T cells actively contribute to chronic inflammatory diseases such as MS.-
dc.format.mimetypeApplication/pdf-
dc.languagenl-
dc.language.isoen-
dc.publishertUL Diepenbeek-
dc.titleThe role of CD28null T cells in autoimmune diseases-
dc.typeTheses and Dissertations-
local.bibliographicCitation.jcatT2-
dc.description.notesmaster in de biomedische wetenschappen-milieu en gezondheid-
local.type.specifiedMaster thesis-
dc.bibliographicCitation.oldjcatD2-
item.contributorBrulmans, Marijke-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.fullcitationBrulmans, Marijke (2011) The role of CD28null T cells in autoimmune diseases.-
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