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http://hdl.handle.net/1942/12825
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DC Field | Value | Language |
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dc.contributor.author | Breusegem, Christophe | - |
dc.contributor.author | Spielberg, Leigh | - |
dc.contributor.author | Van Ginderdeuren, Rita | - |
dc.contributor.author | Vandewalle, Evelien | - |
dc.contributor.author | Renier, Charlotte | - |
dc.contributor.author | Van de Veire, Sara | - |
dc.contributor.author | FIEUWS, Steffen | - |
dc.contributor.author | Zeyen, Thierry | - |
dc.contributor.author | Stalmans, Ingeborg | - |
dc.date.accessioned | 2011-11-29T16:18:25Z | - |
dc.date.available | 2011-11-29T16:18:25Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | OPHTHALMOLOGY, 117(7), p. 1324-1330 | - |
dc.identifier.issn | 0161-6420 | - |
dc.identifier.uri | http://hdl.handle.net/1942/12825 | - |
dc.description.abstract | Purpose: To investigate the benefit of preoperative treatment with either topical nonsteroidal anti-inflammatory drug (NSAID) or steroid in terms of clinical outcomes following trabeculectomy. Design: Prospective, randomized placebo-controlled trial. Participants: Sixty-one patients. Methods: Between July 2005 and October 2007, 61 consecutive medically uncontrolled glaucoma patients scheduled for first-time trabeculectomy were randomized to 1 of 3 study topical medication groups: nonsteroidal anti-inflammatory drugs (ketorolac), steroids (fluorometholone), or placebo (artificial tears). Patients instilled 1 drop 4 times daily for 1 month before the procedure and were examined on days 1 and 2, at weeks 1, 2, and 4, and at months 3, 6, 12, 18, and 24 after trabeculectomy. Main Outcome Measures: Incidence of postoperative surgical or medical interventions (needling, laser suture lysis, needling revision, and intraocular pressure [IOP]-lowering medication). Results: Fifty-four patients (54 eyes) were entered for analysis. The mean number of preoperative medications was 2.3 +/- 0.9. The mean baseline IOP was 21.0 +/- 6.0 mmHg. The mean postoperative target IOP was 16.5 +/- 1.8 mmHg. The mean follow-up was 23.6 +/- 4.0 months. The percentage of patients requiring needling within the first year was 41% in the placebo group, 6% in the NSAID, and 5% in the steroid group (P = 0.006). The percentage of patients requiring IOP-lowering medication to reach the target IOP at 1 year was 24% in the placebo group, 18% in the NSAID group, and 0% in the steroid group (P = 0.054 overall; P = 0.038 for steroids vs. others). The log-rank test showed a significant (P = 0.019) difference in medication-free survival curves between the different groups. More specifically, patients in the steroid group needed significantly less medication over the total follow-up (P = 0.007). Conclusions: Topical ketorolac or fluorometholone for 1 month before surgery was associated with improved trabeculectomy outcomes in terms of likelihood of postoperative needling. In the steroid group, there was a significantly reduced need for additional postoperative IOP-lowering medication compared with the other groups. Financial Disclosure( s): The author( s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2010; 117: 1324-1330 (C) 2010 by the American Academy of Ophthalmology. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Preoperative Nonsteroidal Anti-inflammatory Drug or Steroid and Outcomes after Trabeculectomy A Randomized Controlled Trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1330 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1324 | - |
dc.identifier.volume | 117 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Breusegem, C; Spielberg, L; Van Ginderdeuren, R; Vandewalle, E; Renier, C; Van de Veire, S; Zeyen, T; Stalmans, I] Katholieke Univ Leuven Hosp, Dept Ophthalmol, B-3000 Louvain, Belgium. [Van Ginderdeuren, R; Vandewalle, E; Van de Veire, S; Stalmans, I] Catholic Univ Louvain, Lab Ophthalmol, B-3000 Louvain, Belgium. [Fieuws, S] Catholic Univ Louvain, I Biostat, B-3000 Louvain, Belgium. [Fieuws, S] Univ Hasselt, Hasselt, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1016/j.ophtha.2009.11.038 | - |
dc.identifier.isi | 000279436200007 | - |
item.fulltext | No Fulltext | - |
item.contributor | Breusegem, Christophe | - |
item.contributor | Spielberg, Leigh | - |
item.contributor | Van Ginderdeuren, Rita | - |
item.contributor | Vandewalle, Evelien | - |
item.contributor | Renier, Charlotte | - |
item.contributor | Van de Veire, Sara | - |
item.contributor | FIEUWS, Steffen | - |
item.contributor | Zeyen, Thierry | - |
item.contributor | Stalmans, Ingeborg | - |
item.fullcitation | Breusegem, Christophe; Spielberg, Leigh; Van Ginderdeuren, Rita; Vandewalle, Evelien; Renier, Charlotte; Van de Veire, Sara; FIEUWS, Steffen; Zeyen, Thierry & Stalmans, Ingeborg (2010) Preoperative Nonsteroidal Anti-inflammatory Drug or Steroid and Outcomes after Trabeculectomy A Randomized Controlled Trial. In: OPHTHALMOLOGY, 117(7), p. 1324-1330. | - |
item.accessRights | Closed Access | - |
item.validation | ecoom 2011 | - |
crisitem.journal.issn | 0161-6420 | - |
crisitem.journal.eissn | 1549-4713 | - |
Appears in Collections: | Research publications |
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