Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12825
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dc.contributor.authorBreusegem, Christophe-
dc.contributor.authorSpielberg, Leigh-
dc.contributor.authorVan Ginderdeuren, Rita-
dc.contributor.authorVandewalle, Evelien-
dc.contributor.authorRenier, Charlotte-
dc.contributor.authorVan de Veire, Sara-
dc.contributor.authorFIEUWS, Steffen-
dc.contributor.authorZeyen, Thierry-
dc.contributor.authorStalmans, Ingeborg-
dc.date.accessioned2011-11-29T16:18:25Z-
dc.date.available2011-11-29T16:18:25Z-
dc.date.issued2010-
dc.identifier.citationOPHTHALMOLOGY, 117(7), p. 1324-1330-
dc.identifier.issn0161-6420-
dc.identifier.urihttp://hdl.handle.net/1942/12825-
dc.description.abstractPurpose: To investigate the benefit of preoperative treatment with either topical nonsteroidal anti-inflammatory drug (NSAID) or steroid in terms of clinical outcomes following trabeculectomy. Design: Prospective, randomized placebo-controlled trial. Participants: Sixty-one patients. Methods: Between July 2005 and October 2007, 61 consecutive medically uncontrolled glaucoma patients scheduled for first-time trabeculectomy were randomized to 1 of 3 study topical medication groups: nonsteroidal anti-inflammatory drugs (ketorolac), steroids (fluorometholone), or placebo (artificial tears). Patients instilled 1 drop 4 times daily for 1 month before the procedure and were examined on days 1 and 2, at weeks 1, 2, and 4, and at months 3, 6, 12, 18, and 24 after trabeculectomy. Main Outcome Measures: Incidence of postoperative surgical or medical interventions (needling, laser suture lysis, needling revision, and intraocular pressure [IOP]-lowering medication). Results: Fifty-four patients (54 eyes) were entered for analysis. The mean number of preoperative medications was 2.3 +/- 0.9. The mean baseline IOP was 21.0 +/- 6.0 mmHg. The mean postoperative target IOP was 16.5 +/- 1.8 mmHg. The mean follow-up was 23.6 +/- 4.0 months. The percentage of patients requiring needling within the first year was 41% in the placebo group, 6% in the NSAID, and 5% in the steroid group (P = 0.006). The percentage of patients requiring IOP-lowering medication to reach the target IOP at 1 year was 24% in the placebo group, 18% in the NSAID group, and 0% in the steroid group (P = 0.054 overall; P = 0.038 for steroids vs. others). The log-rank test showed a significant (P = 0.019) difference in medication-free survival curves between the different groups. More specifically, patients in the steroid group needed significantly less medication over the total follow-up (P = 0.007). Conclusions: Topical ketorolac or fluorometholone for 1 month before surgery was associated with improved trabeculectomy outcomes in terms of likelihood of postoperative needling. In the steroid group, there was a significantly reduced need for additional postoperative IOP-lowering medication compared with the other groups. Financial Disclosure( s): The author( s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2010; 117: 1324-1330 (C) 2010 by the American Academy of Ophthalmology.-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE INC-
dc.titlePreoperative Nonsteroidal Anti-inflammatory Drug or Steroid and Outcomes after Trabeculectomy A Randomized Controlled Trial-
dc.typeJournal Contribution-
dc.identifier.epage1330-
dc.identifier.issue7-
dc.identifier.spage1324-
dc.identifier.volume117-
local.format.pages7-
local.bibliographicCitation.jcatA1-
dc.description.notes[Breusegem, C; Spielberg, L; Van Ginderdeuren, R; Vandewalle, E; Renier, C; Van de Veire, S; Zeyen, T; Stalmans, I] Katholieke Univ Leuven Hosp, Dept Ophthalmol, B-3000 Louvain, Belgium. [Van Ginderdeuren, R; Vandewalle, E; Van de Veire, S; Stalmans, I] Catholic Univ Louvain, Lab Ophthalmol, B-3000 Louvain, Belgium. [Fieuws, S] Catholic Univ Louvain, I Biostat, B-3000 Louvain, Belgium. [Fieuws, S] Univ Hasselt, Hasselt, Belgium.-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1016/j.ophtha.2009.11.038-
dc.identifier.isi000279436200007-
item.fulltextNo Fulltext-
item.contributorBreusegem, Christophe-
item.contributorSpielberg, Leigh-
item.contributorVan Ginderdeuren, Rita-
item.contributorVandewalle, Evelien-
item.contributorRenier, Charlotte-
item.contributorVan de Veire, Sara-
item.contributorFIEUWS, Steffen-
item.contributorZeyen, Thierry-
item.contributorStalmans, Ingeborg-
item.fullcitationBreusegem, Christophe; Spielberg, Leigh; Van Ginderdeuren, Rita; Vandewalle, Evelien; Renier, Charlotte; Van de Veire, Sara; FIEUWS, Steffen; Zeyen, Thierry & Stalmans, Ingeborg (2010) Preoperative Nonsteroidal Anti-inflammatory Drug or Steroid and Outcomes after Trabeculectomy A Randomized Controlled Trial. In: OPHTHALMOLOGY, 117(7), p. 1324-1330.-
item.accessRightsClosed Access-
item.validationecoom 2011-
crisitem.journal.issn0161-6420-
crisitem.journal.eissn1549-4713-
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