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DC Field | Value | Language |
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dc.contributor.author | KICINSKI, Michal | - |
dc.contributor.author | VANGRONSVELD, Jaco | - |
dc.contributor.author | NAWROT, Tim | - |
dc.date.accessioned | 2012-01-03T11:21:13Z | - |
dc.date.available | 2012-01-03T11:21:13Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | PLOS ONE, 6(10) | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/1942/12876 | - |
dc.description.abstract | Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25-2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI: 2.37-4.15), and for those with affected father 2.35 times (CI: 2.02-2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI: 2.61-7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR: 2.87, CI: 2.21-3.74), than in men aged 65 and older (RR: 1.92, CI: 1.49-2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI: 55.6-63.5%) for men at all ages, 65.2% (CI: 57.7-71.4%) for men younger than 65 and 47.9% (CI: 37.1-56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI: 65.4-85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65). | - |
dc.description.sponsorship | The study was supported by Scientific Fund FWO (URL: www.fwo.be, krediet aan navorsors; 1.5.158.09.N.00), and Michal Kiciński has a Ph.D. fellowship of the Research Foundation – Flanders (FWO). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.rights | © 2011 Kiciński et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.subject.other | Biology; 5 genetic-variants; nationwide register cohort; population-based cohort; african-american men; risk-factors; breast-cancer; history; carcinoma; database | - |
dc.title | An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 10 | - |
dc.identifier.volume | 6 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Kicinski, Michal] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Leuven Univ KULeuven, Dept Publ Hlth, Louvain, Belgium. michal.kicinski@uhasselt.be | - |
local.publisher.place | SAN FRANCISCO | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1371/journal.pone.0027130 | - |
dc.identifier.isi | 000296916000056 | - |
item.contributor | KICINSKI, Michal | - |
item.contributor | VANGRONSVELD, Jaco | - |
item.contributor | NAWROT, Tim | - |
item.validation | ecoom 2012 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | KICINSKI, Michal; VANGRONSVELD, Jaco & NAWROT, Tim (2011) An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis. In: PLOS ONE, 6(10). | - |
crisitem.journal.issn | 1932-6203 | - |
crisitem.journal.eissn | 1932-6203 | - |
Appears in Collections: | Research publications |
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journal.pone.0027130.pdf | Published version | 301.17 kB | Adobe PDF | View/Open |
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