Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12876
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dc.contributor.authorKICINSKI, Michal-
dc.contributor.authorVANGRONSVELD, Jaco-
dc.contributor.authorNAWROT, Tim-
dc.date.accessioned2012-01-03T11:21:13Z-
dc.date.available2012-01-03T11:21:13Z-
dc.date.issued2011-
dc.identifier.citationPLOS ONE, 6(10)-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/1942/12876-
dc.description.abstractStudies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25-2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI: 2.37-4.15), and for those with affected father 2.35 times (CI: 2.02-2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI: 2.61-7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR: 2.87, CI: 2.21-3.74), than in men aged 65 and older (RR: 1.92, CI: 1.49-2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI: 55.6-63.5%) for men at all ages, 65.2% (CI: 57.7-71.4%) for men younger than 65 and 47.9% (CI: 37.1-56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI: 65.4-85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65).-
dc.description.sponsorshipThe study was supported by Scientific Fund FWO (URL: www.fwo.be, krediet aan navorsors; 1.5.158.09.N.00), and Michal Kiciński has a Ph.D. fellowship of the Research Foundation – Flanders (FWO). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.-
dc.language.isoen-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.rights© 2011 Kiciński et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
dc.subject.otherBiology; 5 genetic-variants; nationwide register cohort; population-based cohort; african-american men; risk-factors; breast-cancer; history; carcinoma; database-
dc.titleAn Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis-
dc.typeJournal Contribution-
dc.identifier.issue10-
dc.identifier.volume6-
local.format.pages7-
local.bibliographicCitation.jcatA1-
dc.description.notes[Kicinski, Michal] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Leuven Univ KULeuven, Dept Publ Hlth, Louvain, Belgium. michal.kicinski@uhasselt.be-
local.publisher.placeSAN FRANCISCO-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1371/journal.pone.0027130-
dc.identifier.isi000296916000056-
item.fulltextWith Fulltext-
item.fullcitationKICINSKI, Michal; VANGRONSVELD, Jaco & NAWROT, Tim (2011) An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis. In: PLOS ONE, 6(10).-
item.contributorKICINSKI, Michal-
item.contributorVANGRONSVELD, Jaco-
item.contributorNAWROT, Tim-
item.validationecoom 2012-
item.accessRightsOpen Access-
crisitem.journal.issn1932-6203-
crisitem.journal.eissn1932-6203-
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