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Title: Are we hitting immunity targets? The 2006 age-specific seroprevalence of measles, mumps, rubella, diphtheria and tetanus in Belgium
Authors: Theeten, H.
Hutse, V.
HENS, Niel 
Yavuz, Y.
Hoppenbrouwers, K.
Beutels, P.
Vranckx, R.
Van Damme, P.
Issue Date: 2011
Source: EPIDEMIOLOGY AND INFECTION, 139 (4), p. 494-504
Abstract: Susceptibility to vaccine-preventable diseases in Belgium in 2006 was estimated from a serum survey. Immunoglobulins against measles, mumps, rubella (MMR) and diphtheria at all available ages (1-65 years), and against tetanus in > 40-year-olds, were measured by ELISA. Age-standardized overall seronegativity for MMR was low (3.9%, 8.0%, 10.4%, respectively). However, the World Health Organization's targets for measles elimination were not met in 5- to 24-year-olds and about 1 in 7 women at childbearing age (15-39 years) were seronegative for rubella. In adults > 40 years, tetanus immunity (87.2%, > 0.16 IU/ml) largely exceeded diphtheria immunity (20-45%, > 0.1 IU/ml). Despite free universal vaccination against MMR for more than 20 years and against diphtheria and tetanus for almost 60 years, our study revealed specific age groups remaining at risk for infection with these pathogens.
Notes: Theeten, H (reprint author), [Theeten, H.; Hens, N.; Beutels, P.; Van Damme, P.] Univ Antwerp, Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, B-2610 Antwerp, Belgium. [Hutse, V.; Vranckx, R.] Sci Inst Publ Hlth, Virol Sect, Brussels, Belgium. [Hens, N.] Hasselt Univ, Interuniv Inst Biostat & Bioinformat, Diepenbeek, Belgium. [Hens, N.; Beutels, P.] Univ Antwerp, Ctr Hlth Econ Res & Modelling Infect Dis, B-2610 Antwerp, Belgium. [Hoppenbrouwers, K.] Katholieke Univ Leuven, Dept Youth Hlth Care, Louvain, Belgium.
Keywords: Diphtheria; measles(rubeola); mumps; rubella; tetanus;Diphtheria; measles (rubeola); mumps; rubella; tetanus
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ISSN: 0950-2688
e-ISSN: 1469-4409
DOI: 10.1017/S0950268810001536
ISI #: 000288225200002
Category: A1
Type: Journal Contribution
Validations: ecoom 2012
Appears in Collections:Research publications

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