Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13151
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSughis, Muhammad-
dc.contributor.authorPENDERS, Joris-
dc.contributor.authorHaufroid, Vincent-
dc.contributor.authorNemery, Benoit-
dc.contributor.authorNAWROT, Tim-
dc.date.accessioned2012-02-15T09:36:06Z-
dc.date.available2012-02-15T09:36:06Z-
dc.date.issued2011-
dc.identifier.citationENVIRONMENTAL HEALTH, 10(December 2011)-
dc.identifier.issn1476-069X-
dc.identifier.urihttp://hdl.handle.net/1942/13151-
dc.description.abstractBackground: Exposure to cadmium has been associated with osteoporosis and fracture risk in women and elderly, but studies in children are lacking. In the present study we investigate the association between markers of bone demineralization [urinary calcium (Ca) and deoxypyridinoline (DPD) excretion] and urinary cadmium (Cd) excretion (as an index of lifetime body burden). Methods: 155 schoolchildren from 2 elementary schools in Lahore, Pakistan were included. Urinary Cd was measured as an index of lifetime exposure. We assessed the multivariate-adjusted association of exposure with markers of bone resorption, urinary DPD as well as with Ca excretion. Results: Urinary Cd averaged 0.50 nmol/mmol creatinine and was not influenced by age, height, weight and socio-economic status (SES). Independent of gender, age, height, weight and SES a doubling of urinary Cd was associated with a 1.72 times (p < 0.0001) increase in urinary DPD and, a 1.21 times (p = 0.02) increase in urinary Ca. Additional adjustment for urinary Ca revealed still significant associations between urinary Cd and urinary DPD. The shape of the association was linear without evidence of a threshold. Conclusions: Even in young children, low-level environmental exposure to cadmium is associated with evidence of bone resorption, suggesting a direct osteotoxic effect with increased calciuria. These findings might have clinical relevance at older age.-
dc.description.sponsorshipThe authors thank the management of the schools for allowing this study to be conducted; the parents of the children for their consent; the children for their participation; and Syed Ihsan-ul-Haque and Asad Amjad for assisting in the collection of urine samples. The work was supported by the Flemish Scientific Fund (kredeiet aan navorsers; G.0.873.11.N.10/1.5.158.09.N.00).-
dc.language.isoen-
dc.publisherBIOMED CENTRAL LTD-
dc.subject.otherChildren; Calcium; Deoxypyridinoline; Environmental Cadmium Exposure; Osteoporosis-
dc.subject.otherEnvironmental Sciences; Public; Environmental & Occupational Health; Children; Calcium; Deoxypyridinoline; Environmental Cadmium Exposure; Osteoporosis-
dc.titleBone resorption and environmental exposure to cadmium in children: a cross-sectional study-
dc.typeJournal Contribution-
dc.identifier.issueDecember 2011-
dc.identifier.volume10-
local.format.pages6-
local.bibliographicCitation.jcatA1-
dc.description.notes[Sughis, Muhammad; Nemery, Benoit; Nawrot, Tim S.] Katholieke Univ Leuven, Dept Publ Hlth Occupat & Environm Med, Unit Lung Toxicol, Louvain, Belgium. [Sughis, Muhammad] Ctr Res Publ Hlth, Lahore, Pakistan. [Sughis, Muhammad] Lahore Coll Pharmaceut Sci, Lahore, Pakistan. [Penders, Joris] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium. [Penders, Joris] Ghent Univ Hosp, Dept Clin Chem Microbiol & Immunol, Ghent, Belgium. [Haufroid, Vincent] Catholic Univ Louvain, Lab Ind Toxicol, B-1200 Brussels, Belgium. [Haufroid, Vincent] Catholic Univ Louvain, Occupat Med Unit, B-1200 Brussels, Belgium. [Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. tim.nawrot@uhasselt.be-
local.publisher.placeLONDON-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1186/1476-069X-10-104-
dc.identifier.isi000298837500001-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.contributorHaufroid, Vincent-
item.contributorSughis, Muhammad-
item.contributorNemery, Benoit-
item.contributorPENDERS, Joris-
item.contributorNAWROT, Tim-
item.fullcitationSughis, Muhammad; PENDERS, Joris; Haufroid, Vincent; Nemery, Benoit & NAWROT, Tim (2011) Bone resorption and environmental exposure to cadmium in children: a cross-sectional study. In: ENVIRONMENTAL HEALTH, 10(December 2011).-
item.validationecoom 2013-
crisitem.journal.issn1476-069X-
crisitem.journal.eissn1476-069X-
Appears in Collections:Research publications
Files in This Item:
File Description SizeFormat 
sughis1.pdfarticle628.01 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

55
checked on Sep 2, 2020

WEB OF SCIENCETM
Citations

64
checked on Jun 29, 2022

Page view(s)

54
checked on Jul 3, 2022

Download(s)

94
checked on Jul 3, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.