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http://hdl.handle.net/1942/13203
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DC Field | Value | Language |
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dc.contributor.author | Emmerechts, Jan | - |
dc.contributor.author | Jacobs, Lotte | - |
dc.contributor.author | Van Kerckhoven, S. | - |
dc.contributor.author | Loyen, S. | - |
dc.contributor.author | Mathieu, Chantal | - |
dc.contributor.author | Fierens, F. | - |
dc.contributor.author | Nemery, Ben | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Hoylaerts, Marc F. | - |
dc.date.accessioned | 2012-02-24T14:23:37Z | - |
dc.date.available | 2012-02-24T14:23:37Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(1), p. 96-106 | - |
dc.identifier.issn | 1538-7933 | - |
dc.identifier.uri | http://hdl.handle.net/1942/13203 | - |
dc.description.abstract | Background: Epidemiological studies suggest an association between exposure to particulate matter (PM) in air pollution and the risk of venous thromboembolism (VTE). Objectives: To investigate the underlying pathophysiological pathways linking PM exposure and VTE. Patients and methods: We assessed potential associations between PM exposure and coagulation and inflammation parameters, including circulating microvesicles, in a group of 233 patients with diabetes. Results: The numbers of circulating blood platelet-derived and annexin V-binding microvesicles were inversely associated with the current levels of PM2.5 or PM10, measured on the day of sampling. Recent past exposure to PM10, up to 1 week prior to blood sampling, estimated at the patients residential addresses, was associated with elevated high-sensitivity C-reactive protein (CRP), leukocytes and fibrinogen, as well as with tissue factor (TF)-dependent procoagulant changes in thrombin generation assays. When longer windows of past exposure were considered, up to 1 year preceding blood sampling, procoagulant changes were evident from the strongly increased numbers of red blood cell-derived circulating microvesicles and annexin V-binding microvesicles, but they no longer associated with TF. Past PM exposure was never associated with activated partial thromboplastin time (aPTT), prothrombin time (PT), or factor (F) VII, FVIII, FXII or D-dimers. Residential distance to a major road was only marginally correlated with procoagulant changes in FVIII and thrombin generation. Conclusions: Increases in the number of microvesicles and in their procoagulant properties, rather than increases in coagulation factors per se, seem to contribute to the risk of VTE, developing during prolonged exposure to air pollutants. | - |
dc.description.sponsorship | J. Emmerechts is holder of a grant from the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen, project 81045). For part of this work, J. Emmerechts received the CSL Behring Heimburger Award in 2011. The C.M.V.B. is supported by the Programmafinanciering KULeuven (PF/10/014). The studies of the Flemish Center of Expertise on Environment and Health were commissioned, financed and steered by the Ministry of the Flemish Community (Department of Economics, Science and Innovation; Flemish Agency for Care and Health; Department of Environment, Nature and Energy). T.N. received a grant of the Flemish Fund for Scientific Research (FWO-Vlaanderen, G.0873.11N/1.2.506.07.N.00). | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.rights | (c) International Society on Thrombosis and Haemostasis | - |
dc.subject.other | air pollution; coagulation; inflammation; microparticles | - |
dc.subject.other | air pollution; coagulation; inflammation; microparticles | - |
dc.title | Air pollution-associated procoagulant changes: the role of circulating microvesicles | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 106 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 96 | - |
dc.identifier.volume | 10 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Emmerechts, J.; Van Kerckhoven, S.; Loyen, S.; Hoylaerts, M. F.] Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium. [Jacobs, L.; Nemery, B.; Nawrot, T. S.] Univ Leuven, Unit Lung Toxicol, Louvain, Belgium. [Mathieu, C.] Univ Hosp Gasthuisberg, Dept Endocrinol, B-3000 Louvain, Belgium. [Fierens, F.] Belgian Interreg Environm Agcy, Brussels, Belgium. [Nawrot, T. S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. | - |
local.publisher.place | MALDEN | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1111/j.1538-7836.2011.04557.x | - |
dc.identifier.isi | 000298843500013 | - |
item.validation | ecoom 2013 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Emmerechts, Jan; Jacobs, Lotte; Van Kerckhoven, S.; Loyen, S.; Mathieu, Chantal; Fierens, F.; Nemery, Ben; NAWROT, Tim & Hoylaerts, Marc F. (2012) Air pollution-associated procoagulant changes: the role of circulating microvesicles. In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(1), p. 96-106. | - |
item.accessRights | Restricted Access | - |
item.contributor | Emmerechts, Jan | - |
item.contributor | Jacobs, Lotte | - |
item.contributor | Van Kerckhoven, S. | - |
item.contributor | Loyen, S. | - |
item.contributor | Mathieu, Chantal | - |
item.contributor | Fierens, F. | - |
item.contributor | Nemery, Ben | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Hoylaerts, Marc F. | - |
crisitem.journal.issn | 1538-7933 | - |
crisitem.journal.eissn | 1538-7836 | - |
Appears in Collections: | Research publications |
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emmerechts1.pdf Restricted Access | Published version | 623.73 kB | Adobe PDF | View/Open Request a copy |
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